The impact of depression on healing outcomes in people with diabetes-related foot ulcers: A systematic review

IF 6.1 3区医学 Q1 ENDOCRINOLOGY & METABOLISM

Diabetes research and clinical practice Pub Date : 2025-05-22 DOI:10.1016/j.diabres.2025.112275

Abeer M. Al-Smadi , Kathleen Finlayson , Brooke Andrew , Christina Parker

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Abstract

This systematic review examined the impact of depression on healing outcomes among people with diabetes-related foot ulcers (DFUs). A comprehensive search of MEDLINE, APA PsycINFO, CINAHL, Embase, and The Cochrane Library was conducted from inception (1976) to 11 March 2024 to identify eligible studies. The Mixed Methods Appraisal Tool (MMAT) was used to assess study quality, and a narrative synthesis was conducted. We identified 1403 articles, of which 11 were included in the final analysis and included a total of 1392 participants with DFUs. The included studies used diagnostic interviews and screening tools to assess depression, and healing outcomes were described as healed ulcer, change in ulcer size, and/or changes in ulcer severity classification tool scores. Of the 11 studies, five studies (45.5 %) found that there was a significant negative impact (or association) of depression on healing outcomes of DFUs. On the other hand, six studies (54.5 %) showed there was no significant impact or association. Three studies were considered high quality, four studies medium quality, and four studies low quality. Depression may have a significant negative impact on healing outcomes in people with DFUs. However, the existing evidence is still unclear, and further high-quality studies are needed to investigate this impact.

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抑郁症对糖尿病相关足溃疡患者愈合结果的影响：一项系统综述

本系统综述研究了抑郁症对糖尿病相关足部溃疡（DFUs）患者愈合结果的影响。从1976年开始到2024年3月11日，对MEDLINE、APA PsycINFO、CINAHL、Embase和Cochrane图书馆进行了全面的检索，以确定符合条件的研究。使用混合方法评估工具（MMAT）评估研究质量，并进行叙事综合。我们确定了1403篇文章，其中11篇被纳入最终分析，共纳入了1392名DFUs患者。纳入的研究使用诊断访谈和筛选工具来评估抑郁症，治疗结果被描述为溃疡愈合，溃疡大小的变化和/或溃疡严重程度分类工具评分的变化。在这11项研究中，有5项研究（45.5% %）发现抑郁症对dfu的愈合结果有显著的负面影响（或关联）。另一方面，六项研究（54.5 %）显示没有显著的影响或关联。3项研究被认为是高质量的，4项研究是中等质量的，4项研究是低质量的。抑郁症可能对dfu患者的康复结果有显著的负面影响。然而，现有的证据仍然不清楚，需要进一步的高质量研究来调查这种影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Diabetes research and clinical practice 医学-内分泌学与代谢

CiteScore

10.30

自引率

3.90%

发文量

862

审稿时长

32 days

期刊介绍： Diabetes Research and Clinical Practice is an international journal for health-care providers and clinically oriented researchers that publishes high-quality original research articles and expert reviews in diabetes and related areas. The role of the journal is to provide a venue for dissemination of knowledge and discussion of topics related to diabetes clinical research and patient care. Topics of focus include translational science, genetics, immunology, nutrition, psychosocial research, epidemiology, prevention, socio-economic research, complications, new treatments, technologies and therapy.