Cognitive Performance in Parkinson's Spectrum Disorders: a comparative study of patients with Parkinson's Disease, Parkinson's Disease Dementia, Dementia With Lewy Bodies, Progressive Supranuclear Palsy, and Corticobasal Syndrome.

IF 3.4 2区心理学 Q1 PSYCHOLOGY, CLINICAL

Assessment Pub Date : 2025-05-24 DOI:10.1177/10731911251339362

Eva A van Breugel, Esther van den Berg, Sanne Franzen, Judy van Hemmen, Harro Seelaar, Caroline van Heugten, Lize C Jiskoot

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引用次数: 0

Abstract

The Parkinson's spectrum encompasses Parkinson's disease (PD), PD dementia (PDD), dementia with Lewy bodies (DLB), progressive supranuclear palsy (PSP), and corticobasal syndrome (CBS). Clinical diagnosis mainly relies on progression over time and neuroimaging, biomarkers, and neurological observations, aided by neuropsychological assessment. Neuropsychological profiles and differences within the Parkinson's spectrum have been understudied. This retrospective study analyzed mean performance and proportions of impairment of neuropsychological assessments of 212 patients in the Parkinson's spectrum at an academic outpatient memory clinic. Patients with PD scored significantly higher than the other patient groups on most tests. The other patient groups showed limited significant differences from one another. The letter fluency test was most effective in distinguishing PD from the other disorders. The auditory verbal learning test was suitable to distinguish PDD and DLB from the other disorders. Results indicate considerable overlap in cognitive profiles across Parkinson's spectrum disorders, suggesting neuropsychological assessment is valuable for assessing cognitive function, guiding post-diagnostic support, and monitoring progression, rather than differential diagnosis.

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帕金森谱系障碍患者的认知表现：帕金森病、帕金森病痴呆、路易体痴呆、进行性核上性麻痹和皮质基底综合征患者的比较研究

帕金森谱系包括帕金森病（PD）、帕金森痴呆（PDD）、路易体痴呆（DLB）、进行性核上性麻痹（PSP）和皮质基底综合征（CBS）。临床诊断主要依赖于随时间的进展和神经影像学、生物标志物和神经学观察，辅以神经心理学评估。帕金森氏症谱系内的神经心理学特征和差异尚未得到充分研究。本回顾性研究分析了在学术门诊记忆诊所就诊的212名帕金森谱系患者的平均表现和神经心理评估损伤的比例。PD患者在大多数测试中的得分明显高于其他患者组。其他患者组之间表现出有限的显著差异。字母流畅性测试是区分PD与其他障碍最有效的方法。听觉言语学习测验适合区分PDD和DLB与其他障碍。结果表明，帕金森谱系障碍的认知特征有相当大的重叠，这表明神经心理学评估对评估认知功能、指导诊断后支持和监测进展有价值，而不是鉴别诊断。

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来源期刊

Assessment PSYCHOLOGY, CLINICAL-

CiteScore

8.90

自引率

2.60%

发文量

期刊介绍： Assessment publishes articles in the domain of applied clinical assessment. The emphasis of this journal is on publication of information of relevance to the use of assessment measures, including test development, validation, and interpretation practices. The scope of the journal includes research that can inform assessment practices in mental health, forensic, medical, and other applied settings. Papers that focus on the assessment of cognitive and neuropsychological functioning, personality, and psychopathology are invited. Most papers published in Assessment report the results of original empirical research, however integrative review articles and scholarly case studies will also be considered.