Mehmet Arif Icer, Hilal Yıldıran, Asife Sahinarslan, Salih Topal, Yakup Yalcın
{"title":"Serum Fetuin-A Affected by Nutritional Status as a Novel Biomarker for Coronary Artery Disease.","authors":"Mehmet Arif Icer, Hilal Yıldıran, Asife Sahinarslan, Salih Topal, Yakup Yalcın","doi":"10.6515/ACS.202505_41(3).20241201A","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>The mechanisms underlying coronary artery disease (CAD), which is characterized by atherosclerotic plaque accumulation in the arteries, are still not fully understood. The role of serum fetuin-A level in the development of CAD and its effects on other risk factors are important research topics that have attracted increasing attention. The aim of this study was to evaluate serum fetuin-A level and the effects of nutritional status on serum fetuin-A concentration in CAD patients.</p><p><strong>Methods: </strong>The study was carried out on 47 male participants (case group) who were newly diagnosed with CAD by conventional coronary angiography and 40 male participants without CAD (control group) aged between 35-75 years. Biochemical parameters, anthropometric measurements and three-day food records of all participants were recorded. In addition, Gensini and SYNTAX scores were calculated using angiography images to determine the extent and severity of CAD.</p><p><strong>Results: </strong>Serum fetuin-A concentration in the case group was higher than that in the control group (p < 0.001). Waist circumference, hip circumference, waist/height ratio, Gensini and SYNTAX scores and serum fetuin-A levels in the participants in the case group were positively correlated (p < 0.05). In addition, there were negative correlations between serum fetuin-A concentration and dietary polyunsaturated fatty acids, omega-6 fatty acids, vitamin E, vitamin B<sub>1</sub>, folate, potassium, and selenium intake in the participants in the case group (p < 0.05).</p><p><strong>Conclusions: </strong>The results of the study indicate that high serum fetuin-A levels may be a risk factor for the development of CAD, and that nutritional status might affect serum fetuin-A level.</p>","PeriodicalId":6957,"journal":{"name":"Acta Cardiologica Sinica","volume":"41 3","pages":"335-345"},"PeriodicalIF":1.8000,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12099234/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta Cardiologica Sinica","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.6515/ACS.202505_41(3).20241201A","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}
引用次数: 0
Abstract
Background: The mechanisms underlying coronary artery disease (CAD), which is characterized by atherosclerotic plaque accumulation in the arteries, are still not fully understood. The role of serum fetuin-A level in the development of CAD and its effects on other risk factors are important research topics that have attracted increasing attention. The aim of this study was to evaluate serum fetuin-A level and the effects of nutritional status on serum fetuin-A concentration in CAD patients.
Methods: The study was carried out on 47 male participants (case group) who were newly diagnosed with CAD by conventional coronary angiography and 40 male participants without CAD (control group) aged between 35-75 years. Biochemical parameters, anthropometric measurements and three-day food records of all participants were recorded. In addition, Gensini and SYNTAX scores were calculated using angiography images to determine the extent and severity of CAD.
Results: Serum fetuin-A concentration in the case group was higher than that in the control group (p < 0.001). Waist circumference, hip circumference, waist/height ratio, Gensini and SYNTAX scores and serum fetuin-A levels in the participants in the case group were positively correlated (p < 0.05). In addition, there were negative correlations between serum fetuin-A concentration and dietary polyunsaturated fatty acids, omega-6 fatty acids, vitamin E, vitamin B1, folate, potassium, and selenium intake in the participants in the case group (p < 0.05).
Conclusions: The results of the study indicate that high serum fetuin-A levels may be a risk factor for the development of CAD, and that nutritional status might affect serum fetuin-A level.
期刊介绍：
Acta Cardiologica Sinica welcomes all the papers in the fields related to cardiovascular medicine including basic research, vascular biology, clinical pharmacology, clinical trial, critical care medicine, coronary artery disease, interventional cardiology, arrythmia and electrophysiology, atherosclerosis, hypertension, cardiomyopathy and heart failure, valvular and structure cardiac disease, pediatric cardiology, cardiovascular surgery, and so on. We received papers from more than 20 countries and areas of the world. Currently, 40% of the papers were submitted to Acta Cardiologica Sinica from Taiwan, 20% from China, and 20% from the other countries and areas in the world. The acceptance rate for publication was around 50% in general.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
