The Clinical Evaluation of Serum WS Biotin, a Novel Encapsulated Form of D-Biotin With Improved Water Solubility, for Anti-Hair Shedding Applications. A Prospective Single-Arm, Nonrandomized, Pretest−Posttest Study

IF 2.1 Q2 MEDICINE, GENERAL & INTERNAL

Health Science Reports Pub Date : 2025-05-26 DOI:10.1002/hsr2.70862

David González Fernández, Shaher Duchi, Lucía Fernández Gómez, Teresa León Sala, Akram Hajuj, Danit Molho, Nadeen Abo Saada, Daniel Molina Martínez, Alejandro Pérez-Fernández, Danny Goldstein

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引用次数: 0

Abstract

Background and Aims

Hair shedding is an aesthetic concern increasingly being addressed by the cosmetic industry. Biotin has long been used as an oral supplement to promote hair growth and strength, without solid evidence supporting this practice. Recently, we have shown that encapsulated biotin has promising bioactivity in hair growth-related parameters in vitro. For this reason, this study aimed at evaluating the association between the application of Serum WS Biotin, a novel water-soluble form of D-Biotin, and hair shedding and strength, after topical application for 3 months.

Methods

A cohort of 22 volunteers with moderate to excessive hair shedding was subjected to daily application of Serum WS Biotin for 3 months. Baseline and follow-up (Days 30, 60, and 90 after the application started) Modified Pull Test (MPT), Modified Hair Wash Test (MHWT), and phototrichogrametry measurements were conducted on the study cohort.

Results

Hairs pulled through MPT were reduced by 43.0% at D30, 56.0% at D60, and 76.1% at D90. Regarding MHWT, the number of vellus hairs (< 3 cm) was significantly reduced by 90.6% at D30, 67.0% at D60, and 74.8% at D90. Concomitantly, pulled hairs > 3 cm significantly diminished by 69.4% at D60 and 60.0% at D90. Contrarily, a significant increase of 227.5% was recorded at D30. Last, the hair thickness median rose significantly by 7.5% at D30, 10.6% at D60, and 7.6% at D90. Consistently, hair thickness mean was nonsignificantly increased by 4.6% at D30, 18.0% at D60, and 17.8% at D90. Interestingly, results also provided a nonstatistically significant improvement in hair mass by 3.2% at D30 and 10.4% at D90.

Conclusion

The 3-month application of Serum WS Biotin displays anti-hair shedding and strengthening capabilities, showing good cutaneous acceptability and compatibility.

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血清WS生物素是一种新型水溶性d -生物素胶囊，用于抗脱发的临床评价。一项前瞻性单组、非随机、前测-后测研究

背景和目的脱发是化妆品行业日益关注的审美问题。生物素长期以来一直被用作促进头发生长和强度的口服补充剂，但没有确凿的证据支持这种做法。最近，我们已经证明包封生物素在头发生长相关参数中具有良好的生物活性。因此，本研究旨在评估局部应用3个月后，血清WS生物素（一种新型水溶性d -生物素）与毛发脱落和强度之间的关系。方法选取22名中度至重度脱发的志愿者，连续3个月每日应用血清WS生物素。基线和随访（应用开始后30、60和90天）对研究队列进行改良拉扯试验（MPT）、改良洗发试验（MHWT）和光电泳测量。结果D30、D60、D90时拔毛量分别减少43.0%、56.0%和76.1%。对于MHWT，在D30、D60和D90时，牛皮毛（3 cm）数量分别显著减少90.6%、67.0%和74.8%。同时，3 cm的拔毛量在D60和D90分别显著减少69.4%和60.0%。相反，在D30时，记录了227.5%的显著增长。最后，在D30、D60和D90时，毛厚中位数分别显著提高了7.5%、10.6%和7.6%。同样，毛发厚度平均在D30、D60和D90时分别增加了4.6%、18.0%和17.8%。有趣的是，结果还显示，在D30和D90时，头发质量的改善无统计学意义，分别为3.2%和10.4%。结论血清WS生物素应用3个月后具有抗脱毛和强化能力，具有良好的皮肤可接受性和相容性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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