Investigating the Relationship Between Serum Uric Acid and Dyslipidemia in Young Adults in Bangladesh

IF 2.6 Q3 ENDOCRINOLOGY & METABOLISM

Endocrinology, Diabetes and Metabolism Pub Date : 2025-05-27 DOI:10.1002/edm2.70063

Abu Taher, Aporajita Das Trisha, Shamim Ahmed, Jannat Begum, Falguni Sinha, Nusrat Zaman Sarna, Nurshad Ali

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Abstract

Objectives

While some reports exist on the relationship between serum uric acid (SUA) and dyslipidemia in adults, there is limited information available regarding young adults. This study aimed to evaluate the relationship between SUA and dyslipidemia, as well as its components, among young adults in Bangladesh.

Methods

This study consisted of 458 participants (281 male and 177 female) aged between 18 and 30 years. The levels of SUA, fasting blood glucose and lipid profile (TG, TC, HDL-C and LDL-C) were measured using standard colorimetric methods. Bivariate logistic regression modelling was used to examine the relationship between SUA and dyslipidemia and its components.

Results

The overall prevalence of hyperuricemia was 24% with 27.6% in males and 18.6% in females. Males had a higher mean SUA level (6.6 ± 1.5 mg/dL) than females (5.3 ± 1.2 mg/dL) (p < 0.001). The prevalence of dyslipidemia was 74.2% with 83.2% in male and 59.8% in female subjects. The prevalence of hypertriglyceridemia, hypercholesterolemia, high LDL-C and low HDL-C was 30.1%, 26.2%, 28.8% and 64.8%, respectively. There was an increasing trend in the level and prevalence of elevated lipid profile markers across the SUA quartiles (p < 0.001). SUA level showed a positive correlation with TG, TC and LDL-C and a negative correlation with HDL (p < 0.001). In regression analysis, a significant association was found between SUA and dyslipidemia in all participants as well as in the male–female groups separately (at least p < 0.05). Furthermore, a significant association (p < 0.001) was found between SUA and individual lipid components in the regression models.

Conclusion

Dyslipidemia and its components were more prevalent in individuals with hyperuricemia than in those without. This study identified a significant association between SUA and dyslipidemia in young adults in Bangladesh. Further research is needed to explore the mechanisms behind this association.

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调查孟加拉年轻人血清尿酸与血脂异常的关系

虽然有一些关于成人血清尿酸（SUA）与血脂异常之间关系的报道，但关于年轻人的信息有限。本研究旨在评估孟加拉国年轻人中SUA与血脂异常及其组成部分之间的关系。方法本研究包括458名参与者（男性281名，女性177名），年龄在18至30岁之间。采用标准比色法测定SUA水平、空腹血糖和血脂（TG、TC、HDL-C和LDL-C）。双变量logistic回归模型用于检验SUA与血脂异常及其组成部分之间的关系。结果高尿酸血症总患病率为24%，其中男性为27.6%，女性为18.6%。男性的平均SUA水平（6.6±1.5 mg/dL）高于女性（5.3±1.2 mg/dL）（p < 0.001）。血脂异常患病率为74.2%，其中男性83.2%，女性59.8%。高甘油三酯血症、高胆固醇血症、高LDL-C和低HDL-C患病率分别为30.1%、26.2%、28.8%和64.8%。在SUA四分位数中，血脂标记物升高的水平和流行率呈上升趋势（p < 0.001）。SUA水平与TG、TC、LDL-C呈正相关，与HDL呈负相关（p < 0.001）。在回归分析中，SUA与血脂异常在所有参与者以及男女组中均存在显著相关性（p < 0.05）。此外，在回归模型中发现SUA与个体脂质成分之间存在显著关联（p < 0.001）。结论高尿酸血症患者血脂异常及其组成部分的发生率高于无高尿酸血症患者。该研究确定了SUA与孟加拉国年轻人血脂异常之间的显著关联。需要进一步的研究来探索这种关联背后的机制。

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