Terahertz nanoantenna sensor for detection of biomarker L-2-Hydroxyglutarate, design optimization and testing

IF 3.3 3区工程技术 Q2 ENGINEERING, ELECTRICAL & ELECTRONIC

Optical and Quantum Electronics Pub Date : 2025-05-26 DOI:10.1007/s11082-025-08260-7

Olga P. Cherkasova, Sergei A. Kuznetsov, Alina A. Rybak, Maria R. Konnikova, Dmitry E. Utkin, Nazar A. Nikolaev

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引用次数: 0

Abstract

L-2-Hydroxyglutarate (L-2HG) plays a significant role in many physiological processes and is considered as a biomarker for various types of oncology. So, its rapid and quantitative measurement in tissues and body fluids is of great clinical importance. The goal of this work is to develop highly efficient photonic sensor for L-2HG using the effect of nanoantenna-assisted plasmonic enhancement of terahertz absorption. We present the numerical results of the design optimization for L-2HG sensor based on Si/SiO₂-wafer-backed arrays of golden nanoantennas (NA) of linear geometry for the resonant frequency of 1.337 THz. NA sensor was fabricated by nanolithography, characterized by scanning electron microscope and tested with terahertz time-domain spectroscopy (THz-TDS). Experimental validation of the NA sensor showed its specific sensitivity to L-2HG. A number of methods have been proposed to improve the accuracy of the NA sensor characterized using THz-TDS technique by an order of magnitude.

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太赫兹纳米天线传感器检测生物标志物l -2-羟基戊二酸，设计优化和测试

l -2-羟戊二酸（L-2HG）在许多生理过程中起着重要作用，被认为是多种肿瘤的生物标志物。因此，在组织和体液中快速定量测定其含量具有重要的临床意义。本工作的目标是利用纳米天线辅助等离子体增强太赫兹吸收的效应，开发高效的L-2HG光子传感器。在1.337 THz谐振频率下，给出了基于硅/二氧化硅衬底线性几何金纳米天线（NA）阵列的L-2HG传感器优化设计的数值结果。采用纳米光刻技术制备NA传感器，用扫描电子显微镜对传感器进行表征，并用太赫兹时域光谱（THz-TDS）对传感器进行测试。实验验证了NA传感器对L-2HG的特异灵敏度。为了将太赫兹- tds技术表征的NA传感器精度提高一个数量级，已经提出了许多方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Optical and Quantum Electronics 工程技术-工程：电子与电气

CiteScore

4.60

自引率

20.00%

发文量

810

审稿时长

3.8 months

期刊介绍： Optical and Quantum Electronics provides an international forum for the publication of original research papers, tutorial reviews and letters in such fields as optical physics, optical engineering and optoelectronics. Special issues are published on topics of current interest. Optical and Quantum Electronics is published monthly. It is concerned with the technology and physics of optical systems, components and devices, i.e., with topics such as: optical fibres; semiconductor lasers and LEDs; light detection and imaging devices; nanophotonics; photonic integration and optoelectronic integrated circuits; silicon photonics; displays; optical communications from devices to systems; materials for photonics (e.g. semiconductors, glasses, graphene); the physics and simulation of optical devices and systems; nanotechnologies in photonics (including engineered nano-structures such as photonic crystals, sub-wavelength photonic structures, metamaterials, and plasmonics); advanced quantum and optoelectronic applications (e.g. quantum computing, memory and communications, quantum sensing and quantum dots); photonic sensors and bio-sensors; Terahertz phenomena; non-linear optics and ultrafast phenomena; green photonics.