Risk Factors and Lesion Patterns in Treatment-Resistant Scabies: Impact of Sex, Age, and Comorbidities

IF 1.5 3区 农林科学 Q4 PARASITOLOGY
Arzu Ferhatosmanoğlu, Leyla Baykal Selçuk, İbrahim Etem Arıca
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Abstract

Purpose

Scabies is a common parasitic skin condition with significant morbidity. This study aimed to identify risk factors for treatment failure and analyze lesion distribution patterns in relation to sex, age, and comorbidities in patients with treatment-resistant scabies.

Methods

The study included patients with dermatologist-confirmed scabies who had received at least one treatment within the past six months without clinical improvement. Clinical, sociodemographic, and cutaneous findings were evaluated.

Results

A total of 246 patients were included (130 females, 52.8%; 116 males, 47.2%). Males had significantly higher rates of excoriation (p < 0.001), pustules (p = 0.047), tunnels (p = 0.046), and genital involvement (p = 0.012). Nodules were more common in individuals under 18 (p = 0.003), while excoriations predominated in those over 65 (p < 0.001). Longer pruritus duration was observed in older adults, rural residents, and patients receiving weekend home visits (p = 0.017, p < 0.001, and p = 0.011, respectively), and was associated with increased lesion severity. A threefold increase in abdominal involvement and a 3.33-fold increase in pustules were seen in patients receiving three or more treatments. Higher education (university or above) was linked to a 46% reduced risk of treatment-resistant scabies.

Conclusions

This study identifies key demographic and clinical risk factors associated with treatment failure in scabies and underscores the need for targeted management strategies. To the best of our knowledge, it is the first to comprehensively investigate lesion distribution and clinical patterns of resistant scabies in relation to sex, age, and comorbid conditions.

难治性疥疮的危险因素和病变模式:性别、年龄和合并症的影响
目的:疥疮是一种常见的寄生虫性皮肤病,发病率高。本研究旨在确定治疗失败的危险因素,并分析难治性疥疮患者的病变分布模式与性别、年龄和合并症的关系。方法本研究纳入了皮肤科医生确诊的疥疮患者,这些患者在过去6个月内至少接受过一次治疗,但没有临床改善。评估临床、社会人口学和皮肤检查结果。结果共纳入246例患者,其中女性130例,占52.8%;男性116人,占47.2%)。男性有明显更高的磨痕(p < 0.001)、脓疱(p = 0.047)、隧道(p = 0.046)和生殖器受累(p = 0.012)。结节在18岁以下的人群中更常见(p = 0.003),而擦伤主要发生在65岁以上的人群中(p < 0.001)。老年人、农村居民和接受周末家访的患者瘙痒持续时间较长(p = 0.017, p <; 0.001和p = 0.011),且与病变严重程度增加相关。在接受三次或三次以上治疗的患者中,腹部受累增加三倍,脓疱增加3.33倍。高等教育(大学或以上)与耐药疥疮风险降低46%有关。结论本研究确定了与疥疮治疗失败相关的关键人口统计学和临床危险因素,并强调了有针对性的管理策略的必要性。据我们所知,这是第一个全面调查与性别、年龄和合并症有关的耐药疥疮的病变分布和临床模式的研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Acta Parasitologica
Acta Parasitologica 医学-寄生虫学
CiteScore
3.10
自引率
6.70%
发文量
149
审稿时长
6-12 weeks
期刊介绍: Acta Parasitologica is an international journal covering the latest advances in the subject. Acta Parasitologica publishes original papers on all aspects of parasitology and host-parasite relationships, including the latest discoveries in biochemical and molecular biology of parasites, their physiology, morphology, taxonomy and ecology, as well as original research papers on immunology, pathology, and epidemiology of parasitic diseases in the context of medical, veterinary and biological sciences. The journal also publishes short research notes, invited review articles, book reviews. The journal was founded in 1953 as "Acta Parasitologica Polonica" by the Polish Parasitological Society and since 1954 has been published by W. Stefanski Institute of Parasitology of the Polish Academy of Sciences in Warsaw. Since 1992 in has appeared as Acta Parasitologica in four issues per year.
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