The safety and effectiveness of oxandrolone on different clinical conditions: A systematic review

Q3 Medicine

Endocrine and Metabolic Science Pub Date : 2025-05-14 DOI:10.1016/j.endmts.2025.100246

Izabelle de Mello Gindri , Gabriel Almeida , Caio Saraiva , Gustavo Ferrari , Darlan Dallacosta , Carlos Rodrigo de Mello Roesler

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引用次数: 0

Abstract

Background

Oxandrolone is a synthetic chemical compound derived from testosterone with a 17-alpha-alkylated structure, showing high potential to enhance the hypermetabolic response and improve clinical outcomes.

Objectives

We aimed to synthesize evidence regarding the safety and effectiveness of Oxandrolone for recognized health problems.

Data sources

A systematic review was performed across six databases using Medical Subject Headings (MeSH) terms and keywords.

Study eligibility criteria, participants, and interventions

We included randomized controlled trials involving children, adolescents, adults, and older adults treated with oral Oxandrolone at doses ranging from 5 to 80 mg.

Study appraisal and synthesis methods

Two reviewers independently conducted the selection, extraction, and quality assessment processes. A protocol was registered in PROSPERO (CRD42024539483).

Results

A total of 24 studies with 1905 participants were included. In children with burns, Oxandrolone increased bone mineral content, preserved lean body mass, and reduced intensive care length of stay. In children with Klinefelter Syndrome, it improved lean body mass and measures of cardiometabolic health. Positive effects on weight and well-being were noted in adults with HIV, and improvements in lean mass and muscle strength were observed in older women. Most reported adverse events were elevated liver enzymes and musculoskeletal complaints.

Limitations

Studies showed heterogeneity in populations, interventions, and outcomes assessed.

Conclusions and implications of key findings

Oxandrolone administration appears to be associated with improvements in body mass, composition indices, and reduced hospitalization time, with a low incidence of side effects. Further investigations are necessary to confirm clinical benefits for specific diseases.

Systematic review registration

PROSPERO CRD42024539483.

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奥胺龙在不同临床条件下的安全性和有效性：一项系统综述

doxandrolone是一种由睾酮衍生的合成化合物，具有17-烷基化结构，具有增强高代谢反应和改善临床结果的潜力。目的：综合有关奥山龙治疗公认健康问题的安全性和有效性的证据。数据来源使用医学主题词（MeSH）术语和关键词对六个数据库进行系统评价。研究资格标准、参与者和干预措施我们纳入了随机对照试验，涉及儿童、青少年、成人和老年人，口服奥雄龙的剂量范围为5 - 80mg。研究评价和综合方法两名审稿人独立进行选择、提取和质量评估过程。协议在PROSPERO中注册（CRD42024539483）。结果共纳入24项研究，受试者1905人。在烧伤儿童中，奥雄龙增加骨矿物质含量，保持瘦体重，缩短重症监护时间。在患有克氏综合征的儿童中，它改善了瘦体重和心脏代谢健康指标。艾滋病毒对成年艾滋病毒感染者的体重和幸福感产生了积极影响，老年妇女的瘦质量和肌肉力量也有所改善。大多数报告的不良事件是肝酶升高和肌肉骨骼不适。局限性：研究显示人群、干预措施和评估结果存在异质性。结论和关键发现的意义：给药索雄龙似乎与改善体重、成分指数和缩短住院时间有关，而且副作用发生率低。需要进一步的研究来证实对特定疾病的临床益处。系统评价注册号prospero CRD42024539483。

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