Bacteriophage therapy for critical antibiotic-resistant Gram-positive bacteria: A systematic review of clinical researches

IF 6.9 1区生物学 Q1 MICROBIOLOGY

Microbiological research Pub Date : 2025-05-22 DOI:10.1016/j.micres.2025.128231

Xinyu Nie , Yigang Tong , Mengzhe Li , Zhenbo Ning , Huahao Fan

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Abstract

The emergence of antibiotic-resistant bacteria compromises medical interventions and poses a significant threat to global public health systems. Bacteriophage (phage) therapy offers a promising, natural, safe, and effective antimicrobial alternative, particularly advantageous for combating Gram-positive bacteria with increasing resistance. This systematic review synthesizes clinical cases published in recent 15 years, evaluating the safety and efficacy of phage therapy in treating Gram-positive bacterial infections. It details the mechanisms of action and applications of phages in treating Gram-positive bacterial infections, critically assessing phage cocktail, phage-assisted regimens, and phage-derived agents. The review further studies phage’s interaction with human host, commensal microbiota, and immune system. Through the rigorous analysis, it identifies phage therapy’s potential implementation obstacles, and provides valuable perspectives for future research and clinical treatment.

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关键耐药革兰氏阳性菌的噬菌体治疗：临床研究的系统回顾

耐抗生素细菌的出现危及医疗干预措施，并对全球公共卫生系统构成重大威胁。噬菌体（噬菌体）治疗提供了一种有前途的、天然的、安全的、有效的抗微生物替代方法，尤其有利于对抗耐药性越来越强的革兰氏阳性细菌。本系统综述综合了近15年来发表的临床病例，评价了噬菌体治疗革兰氏阳性细菌感染的安全性和有效性。它详细介绍了噬菌体在治疗革兰氏阳性细菌感染中的作用机制和应用，批判性地评估了噬菌体鸡尾酒、噬菌体辅助方案和噬菌体衍生药物。本文就噬菌体与人类宿主、共生菌群和免疫系统的相互作用作一综述。通过严谨的分析，明确了噬菌体治疗的潜在实施障碍，为今后的研究和临床治疗提供了有价值的视角。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Microbiological research 生物-微生物学

CiteScore

10.90

自引率

6.00%

发文量

249

审稿时长

29 days

期刊介绍： Microbiological Research is devoted to publishing reports on prokaryotic and eukaryotic microorganisms such as yeasts, fungi, bacteria, archaea, and protozoa. Research on interactions between pathogenic microorganisms and their environment or hosts are also covered.