Ibrahim A. Khalil , Eiman Musa , Sali Alatasi , Khalid Aawad , Khalid Al-Rumaihi
{"title":"Metastatic renal cell carcinoma to the glans penis: A case report of rare presentation","authors":"Ibrahim A. Khalil , Eiman Musa , Sali Alatasi , Khalid Aawad , Khalid Al-Rumaihi","doi":"10.1016/j.eucr.2025.103064","DOIUrl":null,"url":null,"abstract":"<div><div>Renal cell carcinoma (RCC) accounts for 85 % of kidney tumors, with clear cell histology being the most common subtype. While metastases commonly involve the lungs, bones, liver, and brain, penile metastasis is exceedingly rare. We report a case of a 51-year-old male with clear cell RCC who developed biopsy-confirmed metastasis to the glans penis four months after robotic-assisted radical nephrectomy. Despite adjuvant pembrolizumab, a penile lesion emerged, indicating disease progression. This case highlights the need for vigilant surveillance in high-risk RCC and underscores the importance of imaging and pathology in diagnosing and managing rare metastatic sites.</div></div>","PeriodicalId":38188,"journal":{"name":"Urology Case Reports","volume":"61 ","pages":"Article 103064"},"PeriodicalIF":0.5000,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Urology Case Reports","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2214442025001354","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"UROLOGY & NEPHROLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Renal cell carcinoma (RCC) accounts for 85 % of kidney tumors, with clear cell histology being the most common subtype. While metastases commonly involve the lungs, bones, liver, and brain, penile metastasis is exceedingly rare. We report a case of a 51-year-old male with clear cell RCC who developed biopsy-confirmed metastasis to the glans penis four months after robotic-assisted radical nephrectomy. Despite adjuvant pembrolizumab, a penile lesion emerged, indicating disease progression. This case highlights the need for vigilant surveillance in high-risk RCC and underscores the importance of imaging and pathology in diagnosing and managing rare metastatic sites.
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