Nickel/aluminium oxide as a sustainable and cost-effective catalyst for the Sonogashira coupling reaction

IF 2.1 3区化学 Q2 CHEMISTRY, ORGANIC

Tetrahedron Pub Date : 2025-04-24 DOI:10.1016/j.tet.2025.134678

Priya C. Saroj , Manjunath S. Lokolkar , Sai Srinivas Ponugoti , Priyanka R. Ugale , Bhalchandra M. Bhanage , Shreerang V. Joshi

引用次数: 0

Abstract

In our study, we report a cost-effective and sustainable Sonogashira coupling reaction with Nickel supported on alumina (Ni/Al₂O₃) as a palladium-free catalyst. The procedure effectively couples phenylacetylene and 2-ethynylpyridine with various aryl iodides under optimized conditions and provides a greener route by reducing hazardous waste, cost-effectiveness, and eliminating toxic palladium catalysts. The simplicity of catalyst preparation and reusability of the catalyst make the procedure amenable to large-scale applications in keeping with green chemistry principles.

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镍/氧化铝作为Sonogashira偶联反应的可持续和经济的催化剂

在我们的研究中，我们报告了一种低成本和可持续的Sonogashira偶联反应，镍负载在氧化铝（Ni/Al2O3）上作为无钯催化剂。在优化的条件下，该过程有效地将苯乙炔和2-乙基吡啶与各种芳基碘化物偶联，并通过减少危险废物、成本效益和消除有毒钯催化剂提供了更环保的途径。催化剂制备的简单性和催化剂的可重复使用性使该工艺符合绿色化学原则，适合大规模应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Tetrahedron 化学-有机化学

CiteScore

3.90

自引率

4.80%

发文量

439

审稿时长

34 days

期刊介绍： Tetrahedron publishes full accounts of research having outstanding significance in the broad field of organic chemistry and its related disciplines, such as organic materials and bio-organic chemistry. Regular papers in Tetrahedron are expected to represent detailed accounts of an original study having substantially greater scope and details than that found in a communication, as published in Tetrahedron Letters. Tetrahedron also publishes thematic collections of papers as special issues and ''Reports'', commissioned in-depth reviews providing a comprehensive overview of a research area.