Cortical gyrification patterns associated with neuroticism in panic disorder and healthy individuals

IF 2.1 4区医学 Q3 CLINICAL NEUROLOGY

Psychiatry Research: Neuroimaging Pub Date : 2025-05-21 DOI:10.1016/j.pscychresns.2025.112002

Yeong-Geon Hwang , Geonseop Lee , Hyun-Ju Kim

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引用次数: 0

Abstract

Background

Several studies have demonstrated an association between neuroticism and alterations in cortical folding. However, few studies have investigated the relation between neuroticism and gyrification in panic disorder (PD) patients and healthy controls (HC).

Methods

This study included 102 PD patients and 128 HC. Neuroticism, anxiety symptomatology, ways of coping strategies, and health-related quality of life was evaluated. Voxel-wise correlation analyses using FreeSurfer were conducted to determine the neural correlates of neuroticism related to cortical gyrification.

Results

As neuroticism increased, cortical gyrification of the lingual gyrus decreased significantly in HC, whereas postcentral gyrus gyrification increased while lingual gyrus gyrification decreased in PD patients. Although lingual gyrus gyrification in HC was significantly correlated with social phobia, interoception, and agoraphobia, lingual gyrus gyrification in PD patients revealed significant correlations with emotional coping, physical functioning, and emotional role. The gyrification patterns in the postcentral gyrus was significantly correlated with excessive worry scores.

Conclusions

Our study suggests that increased neuroticism is associated with decreased gyrification patterns in the lingual gyrus in both HC and PD group and increased postcentral gyrus gyrification only in PD group. These gyrification alterations may influence perceived quality of life as well as high levels of anxiety in PD patients.

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与惊恐障碍和健康个体神经质相关的皮质旋回模式

背景：一些研究已经证明了神经质和皮层折叠改变之间的联系。然而，很少有研究调查惊恐障碍（PD）患者和健康对照（HC）神经质和旋转的关系。方法纳入PD患者102例，HC患者128例。评估神经质、焦虑症状、应对策略和健康相关生活质量。使用FreeSurfer进行体素相关分析，以确定与皮质旋转相关的神经质的神经相关性。结果随着神经质的增加，HC患者舌回皮质回回明显减少，PD患者中枢后回回回回增加而舌回回回回减少。HC患者的舌回回回回与社交恐惧症、内感受和广场恐怖症显著相关，PD患者的舌回回回回回回回回与情绪应对、身体功能和情绪角色显著相关。中央后回的旋回模式与过度忧虑得分显著相关。结论神经过敏的增加与HC组和PD组舌回旋转模式的减少有关，而PD组只与中枢后回旋转模式的增加有关。这些回转改变可能会影响PD患者的生活质量和高度焦虑。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Psychiatry Research: Neuroimaging 医学-精神病学

CiteScore

3.80

自引率

0.00%

发文量

审稿时长

22.5 weeks

期刊介绍： The Neuroimaging section of Psychiatry Research publishes manuscripts on positron emission tomography, magnetic resonance imaging, computerized electroencephalographic topography, regional cerebral blood flow, computed tomography, magnetoencephalography, autoradiography, post-mortem regional analyses, and other imaging techniques. Reports concerning results in psychiatric disorders, dementias, and the effects of behaviorial tasks and pharmacological treatments are featured. We also invite manuscripts on the methods of obtaining images and computer processing of the images themselves. Selected case reports are also published.