Nanozymes: An emerging arsenal for the treatment of Candida albicans infection

Abstract

Candida albicans infections, exacerbated by the emergence of drug resistance and biofilm formation, pose a significant threat to human health and challenge current treatment options. Therefore, it is imperative to develop novel and effective therapeutic strategies against this pathogen. Recently, nanozyme-based catalytic therapy (NBCT) has emerged as a promising tool against fungal infections, as these enzyme-like catalytic materials exhibit strong antifungal activity against drug-resistant pathogens. Compared to traditional therapies, NBCT offers broad-spectrum antifungal activity and rarely induces drug resistance. Additionally, NBCT can be combined with other treatment modalities to enhance antifungal efficacy. Research efforts are being expedited to make NBCT applicable for treating various forms of Candida infections. In this perspective paper, we summarize recent progress in NBCT and its combination strategies in the treatment of these infections. Finally, the challenges and prospects of NBCT are discussed.