Understanding tsRNAs: From classification to disease mechanisms

IF 4.6 2区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

iScience Pub Date : 2025-05-09 DOI:10.1016/j.isci.2025.112614

Bo Fang , Kai Wang , Yinghui Li , Bo Li , Xinzhe Chen , Kun Wang , Sumin Yang

引用次数: 0

Abstract

tRNA-derived small RNAs (tsRNAs) are a class of non-coding RNA molecules generated through the cleavage of tRNA, primarily categorized into tRNA-derived fragments (tRFs) and tRNA-derived stress-induced small RNAs (tiRNAs). tsRNAs have been shown to play diverse roles in essential biological processes, such as gene expression regulation, cellular stress response, proliferation, and differentiation. Furthermore, tsRNAs are abnormally expressed in various disease states and play a key role in disease pathogenesis. This article reviews the generation, classification, and nomenclature of tsRNAs, examines their potential biological functions and mechanisms in diseases, and discusses their promise as biomarkers and therapeutic targets. Although tsRNA research is still in its early stages, the potential applications of tsRNAs in disease treatment are promising and warrant further investigation.

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了解tsRNAs：从分类到疾病机制

tRNA-derived small RNAs （tsRNAs）是一类通过tRNA裂解产生的非编码RNA分子，主要分为tRNA-derived fragments （trf）和tRNA-derived stress-induced small RNAs （tirna）。tsRNAs在基因表达调控、细胞应激反应、增殖和分化等重要生物过程中发挥着多种作用。此外，tsRNAs在多种疾病状态下异常表达，在疾病发病机制中发挥关键作用。本文综述了tsRNAs的产生、分类和命名，探讨了它们在疾病中的潜在生物学功能和机制，并讨论了它们作为生物标志物和治疗靶点的前景。虽然tsRNA研究仍处于早期阶段，但tsRNA在疾病治疗中的潜在应用前景广阔，值得进一步研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

iScience Multidisciplinary-Multidisciplinary

CiteScore

7.20

自引率

1.70%

发文量

1972

审稿时长

6 weeks

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