Microwave and Polymer-Assisted Synthesis of Ultrasmall Polydopamine Nanoparticles: Applications as Support for Peroxidase-like Activity and as Intracellular Iron Delivery Platform

IF 3.9 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Langmuir Pub Date : 2025-05-13 DOI:10.1021/acs.langmuir.5c0047710.1021/acs.langmuir.5c00477

Javier Bonet-Aleta*, Ana P. Molina-Martínez, Estefania Chico-Carrasco, Lourdes Irusta, Alba Gonzalez, Miguel Encinas-Gimenez, Clara Marquina, José L. Hueso, Jesús Santamaría* and Víctor Sebastian*,

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引用次数: 0

Abstract

Tuning the size of nanomaterials is a critical factor to consider when designing and optimizing their applications. In this context, polydopamine nanoparticles have demonstrated potential across a wide range of biomedical applications (Battaglini, M.; Emanet, M.; Carmignani, A.; Ciofani, G. Nano Today 2024, 55, 102151). However, achieving ultrasmall sizes remains a significant challenge, as most reported diameters in the literature exceed 50 nm. In this study, we present a method for synthesizing ultrasmall polydopamine nanoparticles (sPDA) with diameters below 5 nm. This is accomplished by employing a capping agent, polyvinylpyrrolidone, in combination with ultrafast microwave-assisted heating under basic pH conditions. Furthermore, we investigate the affinity of the synthesized sPDA nanostructures for various metal ions and observe excellent binding to iron ions. This property opens new avenues for catalytic applications and intracellular iron delivery, surpassing the performance of conventional polydopamine nanoparticles.

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微波和聚合物辅助合成超小聚多巴胺纳米颗粒：作为过氧化物酶样活性支持和细胞内铁递送平台的应用

调整纳米材料的尺寸是设计和优化其应用时需要考虑的关键因素。在这种情况下，聚多巴胺纳米颗粒在广泛的生物医学应用中表现出了潜力(Battaglini， M.；Emanet m;Carmignani, a;杨建军，刘建军。纳米材料的研究进展（英文版）。然而，实现超小尺寸仍然是一个重大挑战，因为文献中大多数报道的直径超过50纳米。在这项研究中，我们提出了一种合成直径小于5 nm的超小聚多巴胺纳米粒子（sPDA）的方法。这是通过使用一种封盖剂——聚乙烯吡咯烷酮，结合在基本pH条件下的超快微波辅助加热来实现的。此外，我们还研究了合成的sPDA纳米结构对各种金属离子的亲和力，并观察到与铁离子的良好结合。这种特性为催化应用和细胞内铁递送开辟了新的途径，超越了传统的聚多巴胺纳米颗粒的性能。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Langmuir 化学-材料科学：综合

CiteScore

6.50

自引率

10.30%

发文量

1464

审稿时长

2.1 months

期刊介绍： Langmuir is an interdisciplinary journal publishing articles in the following subject categories: Colloids: surfactants and self-assembly, dispersions, emulsions, foams Interfaces: adsorption, reactions, films, forces Biological Interfaces: biocolloids, biomolecular and biomimetic materials Materials: nano- and mesostructured materials, polymers, gels, liquid crystals Electrochemistry: interfacial charge transfer, charge transport, electrocatalysis, electrokinetic phenomena, bioelectrochemistry Devices and Applications: sensors, fluidics, patterning, catalysis, photonic crystals However, when high-impact, original work is submitted that does not fit within the above categories, decisions to accept or decline such papers will be based on one criteria: What Would Irving Do? Langmuir ranks #2 in citations out of 136 journals in the category of Physical Chemistry with 113,157 total citations. The journal received an Impact Factor of 4.384*. This journal is also indexed in the categories of Materials Science (ranked #1) and Multidisciplinary Chemistry (ranked #5).