Location matters: defining the architecture of the bronchial wall in health and asthma

IF 27.7 1区医学 Q1 IMMUNOLOGY

Nature Immunology Pub Date : 2025-05-26 DOI:10.1038/s41590-025-02165-z

引用次数: 0

Abstract

Using spatial single-cell transcriptomics of human lung biopsies, we mapped cellular interactions at the airway wall in health and asthma. We identified specialized cellular communities marked by high levels of chemokine and alarmin expression. These cellular hubs likely have a crucial role in immune cell training and become dysregulated in asthma.

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位置问题：确定健康和哮喘的支气管壁结构

利用人类肺活检的空间单细胞转录组学，我们绘制了健康和哮喘患者气道壁的细胞相互作用。我们发现了以高水平趋化因子和警报蛋白表达为特征的特殊细胞群落。这些细胞中枢可能在免疫细胞训练中起着至关重要的作用，在哮喘中变得失调。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Immunology 医学-免疫学

CiteScore

40.00

自引率

2.30%

发文量

248

审稿时长

4-8 weeks

期刊介绍： Nature Immunology is a monthly journal that publishes the highest quality research in all areas of immunology. The editorial decisions are made by a team of full-time professional editors. The journal prioritizes work that provides translational and/or fundamental insight into the workings of the immune system. It covers a wide range of topics including innate immunity and inflammation, development, immune receptors, signaling and apoptosis, antigen presentation, gene regulation and recombination, cellular and systemic immunity, vaccines, immune tolerance, autoimmunity, tumor immunology, and microbial immunopathology. In addition to publishing significant original research, Nature Immunology also includes comments, News and Views, research highlights, matters arising from readers, and reviews of the literature. The journal serves as a major conduit of top-quality information for the immunology community.