UFMylation of ARPC4 facilitates lamellipodia formation and promotes cancer metastasis

IF 10.1 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Nature Structural & Molecular Biology Pub Date : 2025-05-26 DOI:10.1038/s41594-025-01577-7

Miao Wang, Yu-Sheng Cong

引用次数: 0

Abstract

Cell migration is a prerequisite for cancer cell invasion and metastasis. The highlighted study shows that UFMylation of ARPC4 facilitates ARP2/3 complex-mediated lamellipodia formation, thereby promoting cancer cell migration, invasion and metastasis.

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ARPC4的ufmy化促进板足形成，促进肿瘤转移

细胞迁移是癌细胞侵袭和转移的先决条件。重点研究表明，ARPC4的UFMylation促进了ARP2/3复合物介导的板足形成，从而促进癌细胞的迁移、侵袭和转移。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Structural & Molecular Biology BIOCHEMISTRY & MOLECULAR BIOLOGY-BIOPHYSICS

CiteScore

22.00

自引率

1.80%

发文量

160

审稿时长

3-8 weeks

期刊介绍： Nature Structural & Molecular Biology is a comprehensive platform that combines structural and molecular research. Our journal focuses on exploring the functional and mechanistic aspects of biological processes, emphasizing how molecular components collaborate to achieve a particular function. While structural data can shed light on these insights, our publication does not require them as a prerequisite.