{"title":"UFMylation of ARPC4 facilitates lamellipodia formation and promotes cancer metastasis","authors":"Miao Wang, Yu-Sheng Cong","doi":"10.1038/s41594-025-01577-7","DOIUrl":null,"url":null,"abstract":"Cell migration is a prerequisite for cancer cell invasion and metastasis. The highlighted study shows that UFMylation of ARPC4 facilitates ARP2/3 complex-mediated lamellipodia formation, thereby promoting cancer cell migration, invasion and metastasis.","PeriodicalId":18822,"journal":{"name":"Nature structural & molecular biology","volume":"25 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature structural & molecular biology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1038/s41594-025-01577-7","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Cell migration is a prerequisite for cancer cell invasion and metastasis. The highlighted study shows that UFMylation of ARPC4 facilitates ARP2/3 complex-mediated lamellipodia formation, thereby promoting cancer cell migration, invasion and metastasis.
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