Simone Michelini, Maria Elisabetta Greco, Giordano Vespasiani, Federica Trovato, Camilla Chello, Noah Musolff, Carmen Cantisani, Giovanni Pellacani
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引用次数: 0
Abstract
Background: Skin aging represents a para-physiological process related to metabolic imbalances, inflammation, proliferative responses, and oxidative stress. Ending the cycle of inflammation, and oxidative stress represents a way to slow the effects of aging.
Study objective: The aim of our study was to evaluate the benefits of supplements with an herbal mixture based on Venerinase and B-group vitamins, Zinc, and Magnesium in preventing/reducing photoaging by means of objective quantitative analysis of visual skin features obtained by VISIA 2D and stroma and vascular characteristics measured by Optical Coherence Tomography (OCT).
Methods: A prospective clinical study was conducted in 40 participants. They were randomized 1:1 to receive the supplement (Giovina) or placebo. Assessments were conducted at Baseline (T0), after 2 months (T1), and after 4 months (T2). The primary endpoint was to obtain a significant improvement in facial photo/chrono-aging in the treatment arm, as assessed through the evaluation of the Griffith scale. Secondary endpoints were to assess significant changes in skin aging objective features (VISIA) and Optical Coherence Tomography (OCT) parameters.
Results: The treated group showed a significant reduction in the mean Griffith scale score from 4.5 at baseline to 3.76 at T2 (4 months) (p = 0.001). A significant decrease in red areas and a borderline significant reduction in the number of wrinkles have been shown by skin aging objective feature calculation on VISIA 2D photographs. OCT analysis showed a borderline significant reduction in collagen density.
Conclusions: The decrease in vascular pattern and collagen density suggests an anti-inflammatory effect with a potential stromal remodeling in the treated group. This seems to be correlated to the reduction in wrinkles and facial redness.
期刊介绍：
Skin Research and Technology is a clinically-oriented journal on biophysical methods and imaging techniques and how they are used in dermatology, cosmetology and plastic surgery for noninvasive quantification of skin structure and functions. Papers are invited on the development and validation of methods and their application in the characterization of diseased, abnormal and normal skin.
Topics include blood flow, colorimetry, thermography, evaporimetry, epidermal humidity, desquamation, profilometry, skin mechanics, epiluminiscence microscopy, high-frequency ultrasonography, confocal microscopy, digital imaging, image analysis and computerized evaluation and magnetic resonance. Noninvasive biochemical methods (such as lipids, keratin and tissue water) and the instrumental evaluation of cytological and histological samples are also covered.
The journal has a wide scope and aims to link scientists, clinical researchers and technicians through original articles, communications, editorials and commentaries, letters, reviews, announcements and news. Contributions should be clear, experimentally sound and novel.
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