{"title":"Innovative hard tissue bone materials from natural sources: a study on silk sericin and ruthenium-based composites.","authors":"Senthil Rethinam","doi":"10.1080/14786419.2025.2509887","DOIUrl":null,"url":null,"abstract":"<p><p>The purpose of this study was to develop a technique for synthesising hard tissue bone materials (HDBM) using natural components. The HDBM was created with SSP, CaCO<sub>3</sub>, and Ru, mixed with deionised water, and compared to standard implants. Mechanical, physicochemical, and biocompatibility tests were conducted to assess the HDBM. The surface of HDBM was characterised before and after exposure to simulated body fluids. The HDBM showed high mechanical properties, with a compressive strength of 42.43 ± 0.29 MPa and an elongation at break of 31.62% ± 0.69%. Bioactivity tests indicated effective calcium and phosphate deposition on the HDBM. Biocompatibility was assessed using the MTT assay with MG63 (human osteoblast cell line), which revealed increased cell viability on the HDBM. The HDBM demonstrated desirable strength, biocompatibility, and bone mineralisation qualities, indicating its potential for use in large animal models pending necessary permits.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-8"},"PeriodicalIF":1.9000,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Natural Product Research","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1080/14786419.2025.2509887","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
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Abstract
The purpose of this study was to develop a technique for synthesising hard tissue bone materials (HDBM) using natural components. The HDBM was created with SSP, CaCO3, and Ru, mixed with deionised water, and compared to standard implants. Mechanical, physicochemical, and biocompatibility tests were conducted to assess the HDBM. The surface of HDBM was characterised before and after exposure to simulated body fluids. The HDBM showed high mechanical properties, with a compressive strength of 42.43 ± 0.29 MPa and an elongation at break of 31.62% ± 0.69%. Bioactivity tests indicated effective calcium and phosphate deposition on the HDBM. Biocompatibility was assessed using the MTT assay with MG63 (human osteoblast cell line), which revealed increased cell viability on the HDBM. The HDBM demonstrated desirable strength, biocompatibility, and bone mineralisation qualities, indicating its potential for use in large animal models pending necessary permits.
期刊介绍：
The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds.
The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal.
Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section.
All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.
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