Jatropha tanjorensis J.L.Ellis & Saroja inhibited carbon tetrachloride-induced fibrogenesis in Wistar rats.

IF 1.9 3区化学 Q3 CHEMISTRY, APPLIED

Natural Product Research Pub Date : 2025-05-24 DOI:10.1080/14786419.2025.2509137

Ifeoluwa T Oyeyemi, Ifeoluwa T Ajayi, Enivwenaye E W Nabofa

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引用次数: 0

Abstract

Jatropha tanjorensis has been employed to treat various diseases. This study aimed to investigate the mode of action of J. tanjorensis against liver fibrogenesis induced by carbon tetrachloride (CCl₄). Liver fibrosis was induced in male Wistar rats by exposing them to CCl₄ for nine weeks. From weeks 7 to 9, J. tanjorensis extract was administered. The study evaluated the activities of antioxidant enzymes and lipid peroxidation (LPO) levels, expression of TGFβ1 and fibrosis-associated proteins, and liver histology. J. tanjorensis significantly increased the depleted antioxidant activities induced by CCl₄ while significantly reducing the elevated LPO levels caused by CCl₄. Furthermore, it downregulated the upregulation of TGFβ1 and fibrosis-associated proteins induced by CCl₄ and mitigated the liver lesions and collagen deposits resulting from CCl₄ exposure. Overall, J. tanjorensis alleviated liver injury and fibrogenesis by exerting its antioxidant effect and inhibition of TGFβ1.

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麻疯树（Jatropha tanjorensis J.L.Ellis & Saroja）抑制四氯化碳诱导的Wistar大鼠纤维生成。

麻疯树已被用于治疗各种疾病。本研究旨在探讨丹参对四氯化碳（CCl4）诱导的肝纤维化的作用机制。将雄性Wistar大鼠暴露于CCl4中9周，诱导其肝纤维化。第7 ~ 9周给予丹参提取物。该研究评估了抗氧化酶活性和脂质过氧化（LPO）水平、tgf - β1和纤维化相关蛋白的表达以及肝脏组织学。丹参显著提高CCl4诱导的抗氧化活性，显著降低CCl4诱导的LPO水平升高。此外，它还下调了CCl4诱导的tgf - β1和纤维化相关蛋白的上调，减轻了CCl4暴露导致的肝脏病变和胶原沉积。总之，丹参通过抗氧化作用和抑制tgf - β1减轻肝损伤和纤维化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Natural Product Research 化学-医药化学

CiteScore

5.10

自引率

9.10%

发文量

605

审稿时长

2.1 months

期刊介绍： The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds. The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal. Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section. All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.