Tracking complete blood count-derived indices during transition to euthymia in bipolar disorder: a longitudinal study.

IF 1.9 4区医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

Biomarkers in medicine Pub Date : 2025-06-01 Epub Date: 2025-05-24 DOI:10.1080/17520363.2025.2511469

Onur Gökçen, Kader Semra Karataş, Merve Akkuş, Feyza Dönmez, Ceyhun Yilmaz, Mete Arslan Konak

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引用次数: 0

Abstract

Aim: This study aims to investigate changes in the CBC-related inflammatory indices in hospitalized bipolar disorder (BD) patients transitioning from a mood episode to a euthymic state.

Method: BD patients hospitalized for mania or depression were assessed during hospitalization and one month post-discharge in euthymia. In both phases, CBC was assessed, along with the administration of YMRS, HDRS-17, and the CGI.

Results: Ninety-four patients (58 manic, 36 depressive episodes) met the inclusion criteria at both phases. Significant decreases were observed in WBC (p < 0.001), neutrophils (p = 0.002), platelets (p = 0.038), NLR (neutrophil-to-lymphocyte ratio, p = 0.019), AISI (aggregate index of systemic inflammation, p < 0.001), dNLR (derived neutrophil-to-lymphocyte ratio, p = 0.007), SII (systemic immune inflammation index, p = 0.002), and SIRI (systemic inflammation response index, p = 0.003), while eosinophils (p = 0.003), EMR (eosinophil-to-monocyte ratio, p = 0.002), and ENR (eosinophil-to-neutrophil ratio, p = 0.001) increased. After a Bonferroni correction (p < 0.003125), changes in WBC, neutrophils, AISI, SII, SIRI, EMR, and ENR remained significant. Furthermore, differences were also noted between VPA users and non-users.

Conclusion: The study highlights distinctive changes in CBC-related indicators during the transition to euthymia in BD patients. It is the first to investigate specific indices such as AISI, dNLR, EMR, and ENR in BD using a longitudinal design. The findings suggest that CBC-derived inflammation indices are promising tools for monitoring BD clinical progression.

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跟踪全血细胞计数衍生指数在过渡到心境双相情感障碍：纵向研究。

目的：本研究旨在探讨住院双相情感障碍（BD）患者从心境发作过渡到心境状态时cbc相关炎症指数的变化。方法：以躁狂症或抑郁症住院的双相障碍患者在住院期间和出院后1个月的精神状态进行评估。在这两个阶段，对CBC进行评估，同时给予YMRS、HDRS-17和CGI。结果：94例患者（躁狂发作58例，抑郁发作36例）符合两个阶段的纳入标准。WBC （p = 0.002）、血小板（p = 0.038）、NLR（中性粒细胞与淋巴细胞比值，p = 0.019）、AISI（全身炎症聚集指数，p = 0.007）、SII（全身免疫炎症指数，p = 0.002）、SIRI（全身炎症反应指数，p = 0.003）显著降低，而嗜酸性粒细胞（p = 0.003）、EMR（嗜酸性粒细胞与单核细胞比值，p = 0.002）、ENR（嗜酸性粒细胞与中性粒细胞比值，p = 0.001）升高。结论：该研究强调了在BD患者向心境过渡期间cbc相关指标的显著变化。这是第一次使用纵向设计来研究BD中的特定指标，如AISI、dNLR、EMR和ENR。研究结果表明，cbc衍生的炎症指数是监测双相障碍临床进展的有希望的工具。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biomarkers in medicine 医学-医学：研究与实验

CiteScore

3.80

自引率

4.50%

发文量

审稿时长

6-12 weeks

期刊介绍： Biomarkers are physical, functional or biochemical indicators of physiological or disease processes. These key indicators can provide vital information in determining disease prognosis, in predicting of response to therapies, adverse events and drug interactions, and in establishing baseline risk. The explosion of interest in biomarker research is driving the development of new predictive, diagnostic and prognostic products in modern medical practice, and biomarkers are also playing an increasingly important role in the discovery and development of new drugs. For the full utility of biomarkers to be realized, we require greater understanding of disease mechanisms, and the interplay between disease mechanisms, therapeutic interventions and the proposed biomarkers. However, in attempting to evaluate the pros and cons of biomarkers systematically, we are moving into new, challenging territory. Biomarkers in Medicine (ISSN 1752-0363) is a peer-reviewed, rapid publication journal delivering commentary and analysis on the advances in our understanding of biomarkers and their potential and actual applications in medicine. The journal facilitates translation of our research knowledge into the clinic to increase the effectiveness of medical practice. As the scientific rationale and regulatory acceptance for biomarkers in medicine and in drug development become more fully established, Biomarkers in Medicine provides the platform for all players in this increasingly vital area to communicate and debate all issues relating to the potential utility and applications. Each issue includes a diversity of content to provide rounded coverage for the research professional. Articles include Guest Editorials, Interviews, Reviews, Research Articles, Perspectives, Priority Paper Evaluations, Special Reports, Case Reports, Conference Reports and Company Profiles. Review coverage is divided into themed sections according to area of therapeutic utility with some issues including themed sections on an area of topical interest. Biomarkers in Medicine provides a platform for commentary and debate for all professionals with an interest in the identification of biomarkers, elucidation of their role and formalization and approval of their application in modern medicine. The audience for Biomarkers in Medicine includes academic and industrial researchers, clinicians, pathologists, clinical chemists and regulatory professionals.