Hydroxychloroquine for Vulval Lichen Planus.

IF 2.4 4区医学 Q2 OBSTETRICS & GYNECOLOGY

Journal of Lower Genital Tract Disease Pub Date : 2024-10-01 DOI:10.1097/LGT.0000000000000843

Harmony Thompson, Amanda Oakley, Harriet Kennedy

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引用次数: 0

Abstract

Objectives: Vulval lichen planus (VLP) is a chronic inflammatory dermatosis that is often refractory to treatment and results in poor quality of life. The management of recalcitrant disease is not well described in the current literature. Hydroxychloroquine (HCQ) has a role in treating oral and cutaneous lichen planus and may be used in VLP based on expert opinion. This review aimed at adding to the limited existing evidence on the role of HCQ for VLP.

Materials and methods: This is a case series of 23 people with VLP treated with HCQ. Outcomes were assessed based on physician global assessment.

Results: Twenty-three people with a mean age of 66 years were included. Ten patients (44%) had a much improved response to HCQ, 1 patient (4%) had a partial response, and 7 (30%) had minimal/no response to treatment. Five people (22%) experienced side effects that resulted in stopping HCQ.

Conclusions: This series demonstrated some efficacy of HCQ in treating VLP. We are limited by the small participant numbers due to the rarity of this condition and a lack of an objective assessment tool. Further controlled studies are needed to assess the effectiveness and tolerability of HCQ in treating this complex condition.

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羟氯喹治疗外阴扁平地衣。

目的：外阴扁平苔藓（VLP）是一种慢性炎症性皮肤病，通常难以治疗，导致生活质量差。顽固性疾病的管理在目前的文献中没有很好的描述。羟氯喹（HCQ）有治疗口腔和皮肤扁平苔藓的作用，根据专家意见，可用于VLP。本综述旨在补充现有有限的关于HCQ在VLP中的作用的证据。材料和方法：这是一个23例用HCQ治疗的VLP患者的病例系列。结果评估基于医师整体评估。结果：共纳入23例，平均年龄66岁。10名患者（44%）对HCQ有明显改善的反应，1名患者（4%）有部分反应，7名患者（30%）对治疗有最小反应或无反应。5人（22%）经历了导致HCQ停止的副作用。结论：HCQ对VLP有一定的治疗作用。由于这种情况的罕见性和缺乏客观评估工具，我们受到参与者人数少的限制。需要进一步的对照研究来评估HCQ治疗这种复杂疾病的有效性和耐受性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Lower Genital Tract Disease OBSTETRICS & GYNECOLOGY-

CiteScore

6.80

自引率

8.10%

发文量

158

审稿时长

6-12 weeks

期刊介绍： The Journal of Lower Genital Tract Disease is the source for the latest science about benign and malignant conditions of the cervix, vagina, vulva, and anus. The Journal publishes peer-reviewed original research original research that addresses prevalence, causes, mechanisms, diagnosis, course, treatment, and prevention of lower genital tract disease. We publish clinical guidelines, position papers, cost-effectiveness analyses, narrative reviews, and systematic reviews, including meta-analyses. We also publish papers about research and reporting methods, opinions about controversial medical issues. Of particular note, we encourage material in any of the above mentioned categories that is related to improving patient care, avoiding medical errors, and comparative effectiveness research. We encourage publication of evidence-based guidelines, diagnostic and therapeutic algorithms, and decision aids. Original research and reviews may be sub-classified according to topic: cervix and HPV, vulva and vagina, perianal and anal, basic science, and education and learning. The scope and readership of the journal extend to several disciplines: gynecology, internal medicine, family practice, dermatology, physical therapy, pathology, sociology, psychology, anthropology, sex therapy, and pharmacology. The Journal of Lower Genital Tract Disease highlights needs for future research, and enhances health care. The Journal of Lower Genital Tract Disease is the official journal of the American Society for Colposcopy and Cervical Pathology, the International Society for the Study of Vulvovaginal Disease, and the International Federation of Cervical Pathology and Colposcopy, and sponsored by the Australian Society for Colposcopy and Cervical Pathology and the Society of Canadian Colposcopists.