RETRACTION: Nanos2 Promotes Differentiation of Male Germ Cells Basing on the Negative Regulation of Foxd3 and the Treatment of 5-Azadc and TSA

IF 4.5 2区 生物学 Q2 CELL BIOLOGY
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引用次数: 0

Abstract

RETRACTION: W. Zhang, Y. Bi, Y. Wang, M. Wang, D. Li, S. Cheng, J. Jin, T. Li, B. Li, and Y. Zhang, “Nanos2 Promotes Differentiation of Male Germ Cells Basing on the Negative Regulation of Foxd3 and the Treatment of 5-Azadc and TSA,” Journal of Cellular Physiology, 234, no. 4 (2019): 3762–3774, https://doi.org/10.1002/jcp.27139.

The above article, published online on 26 August 2018 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the authors, the journal Editor-in-Chief, Robert Heath; and Wiley Periodicals LLC. The retraction has been agreed due to concerns raised by third parties. Specifically, it was brought to the journal's attention that Nanos2 has not been identified in Gallus gallus. Further investigation confirmed that the gene examined in the article was actually Nos2, which encodes nitric oxide synthase 2 (NOS2), a protein with different and unrelated functions from those proposed in the study. Author B. Li stated that she did not directly participate in the experiments conducted for the study and was unaware of its submission. The corresponding author Y. Zhang, on behalf of the remaining co-authors, stated that they mistakenly assumed Nos2, which serves as an alias for Nanos2 in other species, to be homologous to Nanos2 in chickens. This misidentification undermines the study's rationale, methodology, and conclusions. Accordingly, the article is retracted.

撤回:Nanos2通过负调控Foxd3及5-Azadc和TSA的作用促进雄性生殖细胞的分化
引用本文:张伟,毕勇,王艳,王敏,李东东,程生,金军,李涛,李斌,张勇,“Nanos2对雄性生殖细胞分化的调控作用及其对5-Azadc和TSA的治疗作用”,《细胞生理学报》,第34期,no。4 (2019): 3762-3774, https://doi.org/10.1002/jcp.27139.The上述文章于2018年8月26日在线发表在Wiley online Library (wileyonlinelibrary.com)上,经作者、期刊主编Robert Heath同意撤回;和Wiley期刊有限责任公司。由于第三方提出的担忧,已同意撤回。具体来说,引起该杂志注意的是,在Gallus Gallus中尚未发现Nanos2。进一步的研究证实,文章中检测的基因实际上是Nos2,它编码一氧化氮合酶2 (Nos2),这是一种与研究中提出的功能不同且不相关的蛋白质。提交人B. Li说,她没有直接参与为这项研究进行的实验,也不知道该研究的提交。通讯作者Y. Zhang代表其他共同作者表示,他们错误地认为Nos2(在其他物种中作为Nanos2的别名)与鸡中的Nanos2是同源的。这种错误的识别破坏了研究的基本原理、方法和结论。因此,这篇文章被撤回。
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来源期刊
CiteScore
14.70
自引率
0.00%
发文量
256
审稿时长
1 months
期刊介绍: The Journal of Cellular Physiology publishes reports of high biological significance in areas of eukaryotic cell biology and physiology, focusing on those articles that adopt a molecular mechanistic approach to investigate cell structure and function. There is appreciation for the application of cellular, biochemical, molecular and in vivo genetic approaches, as well as the power of genomics, proteomics, bioinformatics and systems biology. In particular, the Journal encourages submission of high-interest papers investigating the genetic and epigenetic regulation of proliferation and phenotype as well as cell fate and lineage commitment by growth factors, cytokines and their cognate receptors and signal transduction pathways that influence the expression, integration and activities of these physiological mediators. Similarly, the Journal encourages submission of manuscripts exploring the regulation of growth and differentiation by cell adhesion molecules in addition to the interplay between these processes and those induced by growth factors and cytokines. Studies on the genes and processes that regulate cell cycle progression and phase transition in eukaryotic cells, and the mechanisms that determine whether cells enter quiescence, proliferate or undergo apoptosis are also welcomed. Submission of papers that address contributions of the extracellular matrix to cellular phenotypes and physiological control as well as regulatory mechanisms governing fertilization, embryogenesis, gametogenesis, cell fate, lineage commitment, differentiation, development and dynamic parameters of cell motility are encouraged. Finally, the investigation of stem cells and changes that differentiate cancer cells from normal cells including studies on the properties and functions of oncogenes and tumor suppressor genes will remain as one of the major interests of the Journal.
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