Tumor microenvironment responsive nanodrugs for synergistic chemo-chemodynamic therapy in triple negative breast cancer

IF 2.1 4区材料科学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Journal of Nanoparticle Research Pub Date : 2025-05-25 DOI:10.1007/s11051-025-06346-7

Haonan Shi, Tao Li

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引用次数: 0

Abstract

Doxorubicin (DOX) is a widely used antitumor agent in clinical settings, while its efficacy is needed to be improved to achieve efficient tumor therapy. In this study, we utilized manganese oxide nanoparticles to deliver DOX to the tumor site and improve its efficacy. Manganese oxide nanoparticles intelligently decompose in the tumor microenvironment with a mild acidic environment, endowing them with the ability to achieve a pH-responsive DOX release. Moreover, manganese oxide nanoparticles release Mn²⁺ ions as well. The released Mn²⁺ ions catalyze the H₂O₂, which shows high levels in tumors, into hydroxyl radicals through a Fenton-like reaction and fulfill chemodynamic therapy (CDT). In vivo studies indicate that the efficacy of DOX is remarkably improved with the assistance of a Mn²⁺ ions–based CDT activity. These intelligent drug delivery systems with pH responsiveness and synergistic CDT/chemotherapy provide a potential candidate to achieve accurate tumor therapy with high efficacy.

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肿瘤微环境反应纳米药物协同化疗-化疗动力学治疗三阴性乳腺癌

多柔比星（DOX）是临床广泛使用的抗肿瘤药物，但其疗效有待提高，以达到有效的肿瘤治疗。在本研究中，我们利用氧化锰纳米颗粒将DOX输送到肿瘤部位，提高其疗效。氧化锰纳米颗粒在肿瘤微环境中以温和的酸性环境智能分解，使其具有ph响应性DOX释放的能力。此外，氧化锰纳米颗粒也释放出Mn2+离子。释放出的Mn2+离子通过fenton样反应将肿瘤中高浓度的H2O2催化成羟基自由基，完成化学动力治疗（CDT）。体内研究表明，在Mn2+离子为基础的CDT活性的帮助下，DOX的疗效显著提高。这些具有pH响应性和协同CDT/化疗的智能药物传递系统为实现精确高效的肿瘤治疗提供了潜在的候选药物。

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来源期刊

Journal of Nanoparticle Research 工程技术-材料科学：综合

CiteScore

4.40

自引率

4.00%

发文量

198

审稿时长

3.9 months

期刊介绍： The objective of the Journal of Nanoparticle Research is to disseminate knowledge of the physical, chemical and biological phenomena and processes in structures that have at least one lengthscale ranging from molecular to approximately 100 nm (or submicron in some situations), and exhibit improved and novel properties that are a direct result of their small size. Nanoparticle research is a key component of nanoscience, nanoengineering and nanotechnology. The focus of the Journal is on the specific concepts, properties, phenomena, and processes related to particles, tubes, layers, macromolecules, clusters and other finite structures of the nanoscale size range. Synthesis, assembly, transport, reactivity, and stability of such structures are considered. Development of in-situ and ex-situ instrumentation for characterization of nanoparticles and their interfaces should be based on new principles for probing properties and phenomena not well understood at the nanometer scale. Modeling and simulation may include atom-based quantum mechanics; molecular dynamics; single-particle, multi-body and continuum based models; fractals; other methods suitable for modeling particle synthesis, assembling and interaction processes. Realization and application of systems, structures and devices with novel functions obtained via precursor nanoparticles is emphasized. Approaches may include gas-, liquid-, solid-, and vacuum-based processes, size reduction, chemical- and bio-self assembly. Contributions include utilization of nanoparticle systems for enhancing a phenomenon or process and particle assembling into hierarchical structures, as well as formulation and the administration of drugs. Synergistic approaches originating from different disciplines and technologies, and interaction between the research providers and users in this field, are encouraged.