The role of volumetry in sinonasal cancer response assessment to induction chemotherapy, results from two phase II non-randomized controlled prospective multicentric trials: SINTART-1 and SINTART-2

IF 4 2区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Oral oncology Pub Date : 2025-05-25 DOI:10.1016/j.oraloncology.2025.107388

Paolo Rondi , Davide Mattavelli , Vittorio Rampinelli , Alberto Schreiber , Ester Orlandi , Barbara Vischioni , Nicola A. Iacovelli , Giuseppina Calareso , Cristiana Bergamini , Salvatore Alfieri , Paolo Castelnuovo , Paolo Battaglia , Mario Turri-Zanoni , Piero Nicolai , Marco Ferrari , Lisa Licitra , Paolo Bossi , Davide Farina , Marco Ravanelli , Carlo Resteghini

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引用次数: 0

Abstract

Objective

This study aims to identify the best response criteria in patients with sinonasal cancer undergoing induction chemotherapy (IC).

Material and methods

Patients enrolled in SINTART-1 and SINTART-2 were included in this study. Unidimensional diameters (anteroposterior, AP; laterolateral, LL; craniocaudal, CC), maximum axial area (Amax), and volume (V) were performed on MRI by two radiologists. RECIST 1.1 assessment was included as a categorical variable. Variables were evaluated at baseline, after the 1st chemotherapy cycle, and at the best response. Interobserver repeatability was analyzed. Stepwise univariable and multivariable Cox proportional-hazards regression models were used to correlate variables with Disease-Free Survival (DFS) and Overall Survival (OS).

Results

60 patients were included in this study. Interobserver correlation coefficient at baseline and after 1st IC cycle was excellent for V (0.916 and 0.928 respectively), CC diameter (0.96 and 0.863), and AP diameter (0.846 and 0.796), good for LL diameter, and moderate for Amax. RECIST 1.1 criteria after the 1st IC cycle and at best response were not associated with OS and DFS. Volume variation after the 1st IC cycle and at best response was significantly associated with OS (p < 0.0001 and p = 0.002) and DFS (p < 0.0001 and p = 0.005). At the multivariable analysis, V variation after the 1st IC cycle and at best response was the only variable significantly associated with OS (p < 0.001 and p = 0.0019) and DFS (p = 0.0004 and p = 0.004).

Conclusions

Volume variation should be preferred to RECIST 1.1 and other measurements to describe the radiological response to IC in sinonasal cancers.

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容积法在鼻窦癌诱导化疗反应评估中的作用，来自两项II期非随机对照前瞻性多中心试验：SINTART-1和SINTART-2

目的探讨鼻窦癌诱导化疗（IC）的最佳疗效标准。材料和方法本研究纳入了参加SINTART-1和SINTART-2的患者。单维直径(正反位，AP；laterolateral会;由两名放射科医生在MRI上进行颅侧，CC)，最大轴向面积（Amax）和体积(V)。纳入RECIST 1.1评价作为分类变量。在基线、第一个化疗周期后和最佳反应时评估变量。分析了观察者间的重复性。使用逐步单变量和多变量Cox比例风险回归模型将变量与无病生存期（DFS）和总生存期（OS）关联起来。结果本研究共纳入60例患者。在基线和第1个IC周期后，观察者间的相关系数对V（分别为0.916和0.928）、CC直径（分别为0.96和0.863）和AP直径（分别为0.846和0.796）均为优秀，对LL直径为良好，对Amax为中等。第一个IC周期后的RECIST 1.1标准和最佳反应与OS和DFS无关。第一个IC周期后和最佳反应时的体积变化与OS显著相关(p <；0.0001和p = 0.002)和DFS (p <；0.0001和p = 0.005)。在多变量分析中，第一个IC周期后的V变化和最佳反应是唯一与OS显著相关的变量(p <；0.001和p = 0.0019)和DFS （p = 0.0004和p = 0.004）。结论体积变化应优先于RECIST 1.1和其他测量来描述鼻窦癌对IC的放射反应。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Oral oncology 医学-牙科与口腔外科

CiteScore

8.70

自引率

10.40%

发文量

505

审稿时长

20 days

期刊介绍： Oral Oncology is an international interdisciplinary journal which publishes high quality original research, clinical trials and review articles, editorials, and commentaries relating to the etiopathogenesis, epidemiology, prevention, clinical features, diagnosis, treatment and management of patients with neoplasms in the head and neck. Oral Oncology is of interest to head and neck surgeons, radiation and medical oncologists, maxillo-facial surgeons, oto-rhino-laryngologists, plastic surgeons, pathologists, scientists, oral medical specialists, special care dentists, dental care professionals, general dental practitioners, public health physicians, palliative care physicians, nurses, radiologists, radiographers, dieticians, occupational therapists, speech and language therapists, nutritionists, clinical and health psychologists and counselors, professionals in end of life care, as well as others interested in these fields.