Condensate-membrane interactions shape membranes, tune cytoskeletal assembly, and localize mRNAs

Abstract

Biomolecular condensates have emerged as essential subcellular compartments. Although condensates organize biochemistry without a delimiting membrane, condensates frequently interact with membrane surfaces in diverse cellular contexts. Condensates and membranes reciprocally modulate each other, inducing membrane shape changes, establishing domains of distinct lipid composition, and catalyzing reactions within condensates. Here I discuss recent advancements in our understanding of the condensate-membrane interface, with a focus on membrane shaping, lipid organization, cytoskeletal regulation, and mRNA transport. I conclude by suggesting research avenues that may uncover new functions for membrane-associated condensates, with emphasis on the understudied role of RNA in the condensate-membrane interface.