[Translated article] Evaluation of trimethoprim-sulfamethoxazole prescribing and dosage optimisation in a tertiary care hospital

IF 1.3 Q4 PHARMACOLOGY & PHARMACY

FARMACIA HOSPITALARIA Pub Date : 2025-09-01 DOI:10.1016/j.farma.2025.04.006

Maialen Inclán-Conde , Clara Vila-Gallego , Maite Vara-Urruchua , Ana Victoria Aguirrezabal-Arredondo , Óscar Luis Ferreiro-Benéitez , Matxalen Vidal-García , Pamela Ruiz-Rodríguez , José Antonio Domínguez-Menéndez

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Abstract

Objective

Evaluate the impact on improving the appropriateness of prescribing following a pharmaceutical intervention based on the review and optimisation of sulfamethoxazole-trimethoprim prescriptions.

Methods

A before-after intervention study was conducted in a tertiary hospital. The first period, or intervention period, was prospective and ran from September 2021 to January 2022. The second or post-intervention period was retrospective and covered the period March-December 2022.

In case of discrepancy between indication and prescribed and recommended dosage, the physician was notified and the degree of acceptance was recorded. In the post-intervention period, we retrospectively analysed the adequacy of the dosage, checking whether any intervention had been carried out by the Pharmacy Department. Statistical analysis was performed using the chi-square test.

Results

During the intervention period, 69 prescriptions were analysed, and 18 were found to be inappropriate (26%), 12 related to Stenotrophomonas maltophilia infection. In the post-intervention period, 129 prescriptions were reviewed, and 12 were considered inadequate (9%). Statistical analysis of the results obtained in both periods (18/69 and 12/129) showed statistically significant differences (p = 0.0082).

Conclusions

Pharmaceutical intervention in the review and optimisation of prescriptions improves the use of sulfamethoxazole-trimethoprim. The results obtained provide evidence of the importance of pharmaceutical review of such prescriptions.

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某三级医院甲氧苄啶-磺胺甲恶唑处方评价及用量优化。

目的：通过对磺胺甲恶唑-甲氧苄啶处方的回顾和优化，评价药物干预对提高处方适宜性的影响。方法：在某三级医院进行干预前后对照研究。第一阶段，或干预期，是前瞻性的，从2021年9月到2022年1月。第二个或干预后阶段是回顾性的，涵盖2022年3月至12月期间。如果适应症与处方和推荐剂量之间存在差异，应通知医生并记录接受程度。在干预期后，我们回顾性分析了剂量是否充足，检查药剂科是否进行了任何干预。采用卡方检验进行统计学分析。结果：干预期间共分析处方69张，发现处方不合适18张（26%），其中12张与嗜麦芽窄养单胞菌感染有关。干预后，审查了129张处方，其中12张被认为不足（9%）。统计分析两期（18/69和12/129）的结果，差异有统计学意义（p = 0.0082）。结论：药物干预对处方的审查和优化促进了磺胺甲恶唑-甲氧苄啶的使用。所获得的结果证明了这类处方的药物审查的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

FARMACIA HOSPITALARIA PHARMACOLOGY & PHARMACY-

CiteScore

1.90

自引率

21.40%

发文量

审稿时长

37 days

期刊介绍： Una gran revista para acceder a los mejores artículos originales y revisiones de la farmacoterapia actual. Además, es Órgano de expresión científica de la Sociedad Española de Farmacia Hospitalaria, y está indexada en Index Medicus/Medline, EMBASE/Excerpta Médica, Alert, Internacional Pharmaceutical Abstracts y SCOPUS.