Insights from the 2024 pediatric rheumatology basic/translational years in review.

IF 2.8 3区医学 Q1 PEDIATRICS

Pediatric Rheumatology Pub Date : 2025-05-23 DOI:10.1186/s12969-025-01102-6

Jessica L Turnier, Scott W Canna

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引用次数: 0

Abstract

Background: Advances in Pediatric Rheumatology are driven by mechanistic insights from basic and translational science. We have selected and reviewed the most impactful basic/translational science from our "Year in Review (YIR)" presentations from the 2024 Pediatric Rheumatology European Society and American College of Rheumatology Convergence meetings (September and November 2024, respectively).

Main body: We drew from fundamental immunology, human genetics, animal models, and computational & "omic" manuscripts published in the year preceding these meetings. Avoiding overlap with other topics presented in this "Perspectives" series, summarized herein are the major themes we gleaned from that process. These include (1) innovative concepts and tools to study immune health, (2) new mechanistic insights into pediatric rheumatic diseases and (3) novel therapeutic targets and treatment approaches in rheumatic disease.

Conclusions: As part of a living relationship with the basic/translational literature that shapes our field and practice, we hope readers will be inspired to delve more deeply into the topics and manuscripts highlighted in this YIR summary.

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回顾2024年儿科风湿病基础/转化年的见解。

背景：儿童风湿病学的进展是由基础科学和转化科学的机制见解驱动的。我们从2024年欧洲儿科风湿病学会和美国风湿病学会汇聚会议（分别为2024年9月和11月）的“年度回顾（YIR）”报告中选择并回顾了最具影响力的基础/转化科学。主体：我们从会议前一年发表的基础免疫学、人类遗传学、动物模型和计算与“基因组学”手稿中提取。为了避免与本“展望”系列中介绍的其他主题重叠，本文总结了我们从该过程中收集到的主要主题。这些包括(1)研究免疫健康的创新概念和工具，(2)对儿童风湿病的新机制见解，以及(3)风湿病的新治疗靶点和治疗方法。结论：作为影响我们研究领域和实践的基础/翻译文献的一部分，我们希望读者能够受到启发，更深入地研究本年度总结中强调的主题和手稿。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pediatric Rheumatology PEDIATRICS-RHEUMATOLOGY

CiteScore

4.10

自引率

8.00%

发文量

审稿时长

>12 weeks

期刊介绍： Pediatric Rheumatology is an open access, peer-reviewed, online journal encompassing all aspects of clinical and basic research related to pediatric rheumatology and allied subjects. The journal’s scope of diseases and syndromes include musculoskeletal pain syndromes, rheumatic fever and post-streptococcal syndromes, juvenile idiopathic arthritis, systemic lupus erythematosus, juvenile dermatomyositis, local and systemic scleroderma, Kawasaki disease, Henoch-Schonlein purpura and other vasculitides, sarcoidosis, inherited musculoskeletal syndromes, autoinflammatory syndromes, and others.