Metaproteomics in the One Health framework for unraveling microbial effectors in microbiomes.

IF 13.8 1区 生物学 Q1 MICROBIOLOGY
Robert Heyer, Maximilian Wolf, Dirk Benndorf, Sergio Uzzau, Jana Seifert, Lucia Grenga, Martin Pabst, Heike Schmitt, Bart Mesuere, Tim Van Den Bossche, Sven-Bastiaan Haange, Nico Jehmlich, Mariagrazia Di Luca, Manuel Ferrer, Sergio Serrano-Villar, Jean Armengaud, Helge B Bode, Patrick Hellwig, Catherine Robbe Masselot, Renaud Léonard, Paul Wilmes
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引用次数: 0

Abstract

One Health seeks to integrate and balance the health of humans, animals, and environmental systems, which are intricately linked through microbiomes. These microbial communities exchange microbes and genes, influencing not only human and animal health but also key environmental, agricultural, and biotechnological processes. Preventing the emergence of pathogens as well as monitoring and controlling the composition of microbiomes through microbial effectors including virulence factors, toxins, antibiotics, non-ribosomal peptides, and viruses holds transformative potential. However, the mechanisms by which these microbial effectors shape microbiomes and their broader functional consequences for host and ecosystem health remain poorly understood. Metaproteomics offers a novel methodological framework as it provides insights into microbial dynamics by quantifying microbial biomass composition, metabolic functions, and detecting effectors like viruses, antimicrobial resistance proteins, and non-ribosomal peptides. Here, we highlight the potential of metaproteomics in elucidating microbial effectors and their impact on microbiomes and discuss their potential for modulating microbiomes to foster desired functions.

b宏蛋白质组学在同一个健康框架中揭示微生物组中的微生物效应。
一个健康寻求整合和平衡人类、动物和环境系统的健康,这些系统通过微生物群错综复杂地联系在一起。这些微生物群落交换微生物和基因,不仅影响人类和动物的健康,而且还影响关键的环境、农业和生物技术过程。通过包括毒力因子、毒素、抗生素、非核糖体肽和病毒在内的微生物效应物,预防病原体的出现以及监测和控制微生物组的组成具有变革潜力。然而,这些微生物效应物形成微生物组的机制及其对宿主和生态系统健康的更广泛的功能后果仍然知之甚少。宏蛋白质组学提供了一种新的方法框架,通过量化微生物生物量组成、代谢功能和检测病毒、抗微生物抗性蛋白和非核糖体肽等效应物,提供了对微生物动力学的深入研究。在这里,我们强调了宏蛋白质组学在阐明微生物效应物及其对微生物组的影响方面的潜力,并讨论了它们调节微生物组以促进所需功能的潜力。
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来源期刊
Microbiome
Microbiome MICROBIOLOGY-
CiteScore
21.90
自引率
2.60%
发文量
198
审稿时长
4 weeks
期刊介绍: Microbiome is a journal that focuses on studies of microbiomes in humans, animals, plants, and the environment. It covers both natural and manipulated microbiomes, such as those in agriculture. The journal is interested in research that uses meta-omics approaches or novel bioinformatics tools and emphasizes the community/host interaction and structure-function relationship within the microbiome. Studies that go beyond descriptive omics surveys and include experimental or theoretical approaches will be considered for publication. The journal also encourages research that establishes cause and effect relationships and supports proposed microbiome functions. However, studies of individual microbial isolates/species without exploring their impact on the host or the complex microbiome structures and functions will not be considered for publication. Microbiome is indexed in BIOSIS, Current Contents, DOAJ, Embase, MEDLINE, PubMed, PubMed Central, and Science Citations Index Expanded.
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