Pupil dilation evoked by painful electrical stimulation is abolished during pain inhibition by distraction.

IF 2.6 4区 医学 Q2 PHYSIOLOGY
Alice Wagenaar-Tison, Zoha Deldar, Antoine Bergeron, Benjamin Provencher, Stéphane Northon, Nabi Rustamov, Isabelle Blanchette, Sylvain Sirois, Mathieu Piché
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引用次数: 0

Abstract

The aim of the present study was to examine the contribution of spinal and supraspinal processes to pain modulation by attention. It is hypothesized that pain inhibition by distraction is accompanied by reduced pain-evoked pupil dilation and cerebral activity, but no inhibition of the nociceptive flexion reflex (NFR), while pain anticipation is expected to increase pain perception and pain-related responses. Twenty healthy volunteers received 90 painful stimuli in control, distraction (mental arithmetic), and anticipation (visual cue) conditions. Anticipation did not modulate pain (p = .7), while distraction decreased pain significantly (p < .001). Moreover, pupil diameter increased 500-1000 ms post-stimulus in the control condition (p < .05), but this response was abolished by distraction. Distraction also decreased pain-related brain activity (high-gamma oscillations) (p = .004), but not the NFR (p = .3). These results suggest that pain inhibition by distraction is produced, in part, by supraspinal inhibition of nociceptive processes.

由疼痛电刺激引起的瞳孔扩张在分心抑制疼痛时被消除。
本研究的目的是检查脊柱和棘上突对注意调节疼痛的作用。我们假设,分心对疼痛的抑制伴随着疼痛引起的瞳孔扩张和大脑活动的减少,但对伤害性屈曲反射(NFR)没有抑制,而疼痛预期则有望增加疼痛感知和疼痛相关反应。20名健康志愿者在控制、分心(心算)和期待(视觉线索)条件下接受了90种疼痛刺激。预期没有调节疼痛(p = .7),而分心显著降低疼痛(p = .7)
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来源期刊
CiteScore
4.40
自引率
4.30%
发文量
27
审稿时长
6-12 weeks
期刊介绍: The Journal of Physiological Sciences publishes peer-reviewed original papers, reviews, short communications, technical notes, and letters to the editor, based on the principles and theories of modern physiology and addressed to the international scientific community. All fields of physiology are covered, encompassing molecular, cellular and systems physiology. The emphasis is on human and vertebrate physiology, but comparative papers are also considered. The process of obtaining results must be ethically sound. Fields covered: Adaptation and environment Autonomic nervous function Biophysics Cell sensors and signaling Central nervous system and brain sciences Endocrinology and metabolism Excitable membranes and neural cell physiology Exercise physiology Gastrointestinal and kidney physiology Heart and circulatory physiology Molecular and cellular physiology Muscle physiology Physiome/systems biology Respiration physiology Senses.
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