Antibiotic resistance in Helicobacter pylori: a genetic and physiological perspective.

IF 4.3 3区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY

Gut Pathogens Pub Date : 2025-05-23 DOI:10.1186/s13099-025-00704-5

Rania G Elbaiomy, Xiaoling Luo, Rong Guo, Shiyuan Deng, Meifang Du, Ahmed H El-Sappah, Mohammed Bakeer, Mahmoud M Azzam, Ahmed A Elolimy, Mahmoud Madkour, Zaixin Li, Zhi Zhang

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Abstract

The identification of Helicobacter pylori (H. pylori) infection as the primary etiology of gastroduodenal diseases represents a significant advancement in the field of gastroenterology. The management of these diseases has undergone a substantial transformation, and antibiotic treatment is now universally applicable. H. pylori has been the subject of numerous investigations to determine the prevalence of antibiotic resistance. However, many of these studies are limited, particularly regarding the number and representativeness of the strains assessed. Genetic and physiological modifications, such as gene mutations, efflux pump alterations, biofilm formation, and coccoid formation, contribute to the observed resistance. Our review focuses on the emergence of antibiotic-resistant strains, particularly emphasizing the various modifications of H. pylori that confer this resistance. In conclusion, we elucidate the challenges, potential solutions, and prospects in this field, providing researchers with the knowledge necessary to overcome the resistance exhibited by H. pylori.

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幽门螺杆菌的抗生素耐药性：遗传学和生理学的观点。

确定幽门螺杆菌感染是胃十二指肠疾病的主要病因，是胃肠病学领域的重大进展。这些疾病的管理经历了实质性的转变，抗生素治疗现在普遍适用。幽门螺杆菌一直是众多调查的主题，以确定抗生素耐药性的流行。然而，这些研究中有许多是有限的，特别是在评估菌株的数量和代表性方面。遗传和生理改变，如基因突变、外排泵改变、生物膜形成和球虫形成，有助于观察到的耐药性。我们的回顾集中在抗生素耐药菌株的出现，特别强调各种修改幽门螺杆菌赋予这种耐药性。总之，我们阐明了该领域的挑战，潜在的解决方案和前景，为研究人员克服幽门螺杆菌表现出的耐药性提供了必要的知识。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Gut Pathogens GASTROENTEROLOGY & HEPATOLOGY-MICROBIOLOGY

CiteScore

7.70

自引率

2.40%

发文量

期刊介绍： Gut Pathogens is a fast publishing, inclusive and prominent international journal which recognizes the need for a publishing platform uniquely tailored to reflect the full breadth of research in the biology and medicine of pathogens, commensals and functional microbiota of the gut. The journal publishes basic, clinical and cutting-edge research on all aspects of the above mentioned organisms including probiotic bacteria and yeasts and their products. The scope also covers the related ecology, molecular genetics, physiology and epidemiology of these microbes. The journal actively invites timely reports on the novel aspects of genomics, metagenomics, microbiota profiling and systems biology. Gut Pathogens will also consider, at the discretion of the editors, descriptive studies identifying a new genome sequence of a gut microbe or a series of related microbes (such as those obtained from new hosts, niches, settings, outbreaks and epidemics) and those obtained from single or multiple hosts at one or different time points (chronological evolution).