Skin perfusion decreases after dexmedetomidine administration in dogs but remains stable for up to 60 minutes under general anesthesia.

IF 1.3 3区农林科学 Q2 VETERINARY SCIENCES

American journal of veterinary research Pub Date : 2025-05-23 DOI:10.2460/ajvr.25.02.0057

Meghan Watt, James Bilof, Keila K Ida, Nicholas Jeffery, Vanna Dickerson

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引用次数: 0

Abstract

Objective: To determine the effect of general anesthesia on skin perfusion in healthy dogs.

Methods: Client-owned dogs (n = 22) undergoing a dental cleaning procedure were enrolled in a prospective study. All dogs were administered trazodone (4 to 6 mg/kg, PO) the evening prior to and morning of their dental procedure. After premedication (0.2 mg/kg of butorphanol and 4 μg/kg of dexmedetomidine, IM), anesthesia was induced with propofol (4 mg/kg, IV, to effect) and maintained with isoflurane in 100% oxygen. The mean speckle contrast (MSC; inversely proportional to perfusion) was recorded using laser speckle contrast imaging for the pinna, hind limb, neck, and ventral midline prior to any medication, after premedication, and every 15 minutes while under isoflurane anesthesia for 60 minutes. The percentage of change in MSC from baseline was recorded.

Results: MSC increased after premedication versus prior to any medication for all sites, indicating a decrease in perfusion. The magnitude was greater for the ventral midline (37.2 ± 8.1%), neck (28.3 ± 9.5%), and pinna (26.8 ± 6.1%) compared to the hind limb (8.7 ± 3.1%). A mild decrease in MSC (increased perfusion) was observed over time during isoflurane anesthesia. The magnitude was greater for the pinna (-11.0 ± 3.5%) compared to the neck (-1.8 ± 1.6%), midline (8.1 ± 0.2%), and hind limb (3.5 ± 0.6%).

Conclusions: A decrease in skin perfusion following IM dexmedetomidine was seen. No further decrease in skin perfusion was seen over time for up to 60 minutes under isoflurane anesthesia.

Clinical relevance: Veterinarians should not hesitate to place patients under general anesthesia for short durations even when skin perfusion is a concern; however, it may be prudent to avoid dexmedetomidine.

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右美托咪定给药后狗的皮肤灌注减少，但在全身麻醉下保持稳定长达60分钟。

目的：探讨全身麻醉对健康犬皮肤灌注的影响。方法：客户拥有的狗（n = 22）正在进行牙齿清洁程序纳入前瞻性研究。所有狗在牙科手术前一天晚上和早上给予曲唑酮（4至6 mg/kg， PO）。用药前（布托酚0.2 mg/kg，右美托咪定4 μg/kg， IM），异丙酚（4mg /kg，静脉注射，有效）诱导麻醉，异氟烷100%氧维持。平均散斑对比度(MSC；在用药前、用药前、异氟醚麻醉60分钟内，每15分钟用激光散斑造影记录耳廓、后肢、颈部和腹正中线的情况，与灌注成反比。记录MSC从基线变化的百分比。结果：在给药前与给药前相比，所有部位的MSC都增加了，表明灌注减少。与后肢（8.7±3.1%）相比，腹中线（37.2±8.1%）、颈部（28.3±9.5%）和耳廓（26.8±6.1%）的幅度更大。随着异氟醚麻醉时间的推移，MSC轻度降低（灌注增加）。与颈部（-1.8±1.6%）、中线（8.1±0.2%）和后肢（3.5±0.6%）相比，耳廓（-11.0±3.5%）的幅度更大。结论：注射右美托咪定后皮肤灌注减少。在异氟醚麻醉下，在长达60分钟的时间内，皮肤灌注没有进一步减少。临床相关性：兽医应该毫不犹豫地将患者置于短时间全身麻醉下，即使皮肤灌注是一个问题；然而，谨慎地避免使用右美托咪定。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

American journal of veterinary research 农林科学-兽医学

CiteScore

1.70

自引率

10.00%

发文量

186

审稿时长

3 months

期刊介绍： The American Journal of Veterinary Research supports the collaborative exchange of information between researchers and clinicians by publishing novel research findings that bridge the gulf between basic research and clinical practice or that help to translate laboratory research and preclinical studies to the development of clinical trials and clinical practice. The journal welcomes submission of high-quality original studies and review articles in a wide range of scientific fields, including anatomy, anesthesiology, animal welfare, behavior, epidemiology, genetics, heredity, infectious disease, molecular biology, oncology, pharmacology, pathogenic mechanisms, physiology, surgery, theriogenology, toxicology, and vaccinology. Species of interest include production animals, companion animals, equids, exotic animals, birds, reptiles, and wild and marine animals. Reports of laboratory animal studies and studies involving the use of animals as experimental models of human diseases are considered only when the study results are of demonstrable benefit to the species used in the research or to another species of veterinary interest. Other fields of interest or animals species are not necessarily excluded from consideration, but such reports must focus on novel research findings. Submitted papers must make an original and substantial contribution to the veterinary medicine knowledge base; preliminary studies are not appropriate.