Lei Sun , Xiang Geng , Yichong Wang , Daoyuan Wang , Xin Ma , Gangmin Ning
{"title":"Hemodynamic simulation for plantar arteries by anatomical structure based mathematical model","authors":"Lei Sun , Xiang Geng , Yichong Wang , Daoyuan Wang , Xin Ma , Gangmin Ning","doi":"10.1016/j.bbe.2025.05.006","DOIUrl":null,"url":null,"abstract":"<div><div>Diabetic foot is a kind of common complications in diabetic patients, manifesting as ischemic lesions in plantar tissue. The plantar tissue ischemia can be estimated by the perfusion of plantar blood flow. Currently, it lacks effective methods to monitor and assess plantar blood flow perfusion in practice and detailed information is not available. This study intends to address this problem from the view of mathematical modelling. It aims to provide quantitative approach to investigate the risk of ischemia in diabetic foot by simulating the hemodynamic status along the plantar vascular network. A simplified topological structure map of the main plantar arteries was established considering the anatomical structure and physical data of each vessel. Aided by bond graph technology, a Poiseuille’s law based hemodynamic model of the plantar vessels was constructed. The model simulated the blood flow distribution in the feet of healthy individuals and diabetic patients. Compared with healthy individuals, diabetic patients show increased plantar blood pressure and decreased blood supply. The reduction in blood flow on the lateral side of the foot is greater than on the medial side in diabetic patients. The study marks the first application of vascular modeling in the plantar region, providing a quantitative method for investigating foot hemodynamics in diabetic patients and offering new potential for assessing the progression of diabetic foot and the risk of tissue ulceration.</div></div>","PeriodicalId":55381,"journal":{"name":"Biocybernetics and Biomedical Engineering","volume":"45 3","pages":"Pages 390-398"},"PeriodicalIF":6.6000,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biocybernetics and Biomedical Engineering","FirstCategoryId":"5","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0208521625000348","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENGINEERING, BIOMEDICAL","Score":null,"Total":0}
引用次数: 0
Abstract
Diabetic foot is a kind of common complications in diabetic patients, manifesting as ischemic lesions in plantar tissue. The plantar tissue ischemia can be estimated by the perfusion of plantar blood flow. Currently, it lacks effective methods to monitor and assess plantar blood flow perfusion in practice and detailed information is not available. This study intends to address this problem from the view of mathematical modelling. It aims to provide quantitative approach to investigate the risk of ischemia in diabetic foot by simulating the hemodynamic status along the plantar vascular network. A simplified topological structure map of the main plantar arteries was established considering the anatomical structure and physical data of each vessel. Aided by bond graph technology, a Poiseuille’s law based hemodynamic model of the plantar vessels was constructed. The model simulated the blood flow distribution in the feet of healthy individuals and diabetic patients. Compared with healthy individuals, diabetic patients show increased plantar blood pressure and decreased blood supply. The reduction in blood flow on the lateral side of the foot is greater than on the medial side in diabetic patients. The study marks the first application of vascular modeling in the plantar region, providing a quantitative method for investigating foot hemodynamics in diabetic patients and offering new potential for assessing the progression of diabetic foot and the risk of tissue ulceration.
期刊介绍:
Biocybernetics and Biomedical Engineering is a quarterly journal, founded in 1981, devoted to publishing the results of original, innovative and creative research investigations in the field of Biocybernetics and biomedical engineering, which bridges mathematical, physical, chemical and engineering methods and technology to analyse physiological processes in living organisms as well as to develop methods, devices and systems used in biology and medicine, mainly in medical diagnosis, monitoring systems and therapy. The Journal''s mission is to advance scientific discovery into new or improved standards of care, and promotion a wide-ranging exchange between science and its application to humans.