A case of primary pulmonary synovial sarcoma

IF 0.8 Q4 RESPIRATORY SYSTEM

Respiratory Medicine Case Reports Pub Date : 2025-01-01 DOI:10.1016/j.rmcr.2025.102236

Keigo Ozono , Keita Sakanashi , Naoya Iwamoto , Yoshiyuki Nakanishi , Yoshinao Oda , Masafumi Nakamura

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Abstract

Background

Primary pulmonary synovial sarcoma (PPSS) is an extremely rare pulmonary malignancy and often poses diagnostic challenges, especially in differentiating it from benign tumors.

Case presentation

A 46-year-old woman presented with a slowly enlarging, well-defined nodule in the right lower lobe of the lung. Positron emission tomography showed low FDG uptake (SUVmax 1.52), raising suspicion for a benign lesion. However, histopathologic examination following wedge resection revealed primary pulmonary synovial sarcoma. Subsequently, a right lower lobectomy was performed. The patient has remained recurrence-free for over one year.

Conclusions

Surgical resection with clear margins is essential in the management of PPSS. This case highlights the difficulty in distinguishing PPSS from benign lung lesions based on imaging alone, underscoring the importance of pathological confirmation. Accumulation of more reported cases is needed to develop standardized treatment strategies.

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原发性肺滑膜肉瘤1例

背景：原发性肺滑膜肉瘤（PPSS）是一种极其罕见的肺部恶性肿瘤，常常给诊断带来挑战，特别是在与良性肿瘤的鉴别上。病例表现：46岁女性，右肺下叶有一个缓慢增大、界限清晰的结节。正电子发射断层扫描显示低FDG摄取（SUVmax 1.52），引起良性病变的怀疑。然而，楔形切除术后的组织病理学检查显示原发性肺滑膜肉瘤。随后行右下肺叶切除术。病人一年多没有复发。结论手术切除切缘清晰是治疗PPSS的关键。本病例强调了仅凭影像学区分PPSS与肺部良性病变的困难，强调了病理证实的重要性。需要积累更多的报告病例来制定标准化的治疗策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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