Haematological abnormalities as diagnostic indicators of malaria in returning travellers: a retrospective study at Mohamed V Military Instruction Hospital.

Access microbiology Pub Date : 2025-05-21 eCollection Date: 2025-01-01 DOI:10.1099/acmi.0.000919.v3
Nabil Mohamed Zniber, Hamid Laatiris, Hamza Siyar, Abdelouahab Erraji, Ismail Labrouzi, Mohamed Jnah, Mehdi Talbi, Maryem Iken, Badreddine Lmimouni, Hafida Naoui
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Abstract

Introduction. Malaria remains a significant global health concern, particularly in travellers returning from endemic regions. Haematological abnormalities are often associated with malaria and can serve as diagnostic indicators, especially when clinical symptoms are nonspecific. Objective. This study aims to identify the most relevant haematological parameters for diagnosing malaria in travellers returning from endemic areas, who sought care at the Mohamed V Military Instruction Hospital in Rabat. Methods. We conducted a retrospective comparative study involving 829 patients who returned from malaria-endemic regions between January 2017 and December 2023. Data collected included demographic information, parasitological test results and comprehensive haematological profiles. Statistical analysis was performed to determine the sensitivity and specificity of various haematological parameters in diagnosing malaria. Results. Thrombocytopenia, lymphocytopenia and anaemia were the most significant haematological abnormalities associated with malaria. Thrombocytopenia, defined as a platelet count below 150×10³ µl-1, demonstrated a sensitivity of 75.91% and a specificity of 84.11%. Lymphocytopenia, with a threshold of less than 1.5×10³ µl-1, showed a sensitivity of 69.47% and a specificity of 78.39%. Anaemia, defined by haemoglobin levels below 13 g dl-1 in men and 12 g dl-1 in women, also significantly correlated with malaria diagnosis. Discussion. This study highlights the significance of haematological abnormalities as key diagnostic markers for imported malaria cases. By analysing retrospective data, we observed that these abnormalities, especially thrombocytopenia and anaemia, are common amongst returning travellers with confirmed malaria. These findings suggest that clinicians can use such markers as a valuable tool for early malaria diagnosis, potentially improving patient outcomes. Additionally, the study reinforces the need for heightened awareness amongst healthcare providers in non-endemic regions regarding the presentation of malaria in travellers. Conclusion. Haematological parameters such as thrombocytopenia, lymphocytopenia and anaemia are valuable diagnostic tools for malaria in returning travellers. These findings suggest that these parameters should be integrated into diagnostic protocols to improve the accuracy and timeliness of malaria diagnosis, particularly in clinical settings with limited access to advanced diagnostic tools.

血液学异常作为返回旅行者疟疾的诊断指标:穆罕默德五世军事指导医院的回顾性研究。
介绍。疟疾仍然是一个重大的全球健康问题,特别是在从流行地区返回的旅行者中。血液学异常通常与疟疾有关,可作为诊断指标,特别是在临床症状无特异性的情况下。目标。本研究旨在确定从流行地区返回并在拉巴特穆罕默德五世军事指导医院寻求治疗的旅行者中诊断疟疾的最相关血液学参数。方法。我们对2017年1月至2023年12月期间从疟疾流行地区返回的829例患者进行了回顾性比较研究。收集的数据包括人口统计信息、寄生虫学测试结果和综合血液学概况。统计分析各种血液学参数诊断疟疾的敏感性和特异性。结果。血小板减少症、淋巴细胞减少症和贫血是与疟疾相关的最显著的血液学异常。血小板减少症,定义为血小板计数低于150×10³µl-1,灵敏度为75.91%,特异性为84.11%。淋巴细胞减少症的阈值小于1.5×10³µl-1,敏感性为69.47%,特异性为78.39%。贫血,即男性血红蛋白水平低于13 g dl-1,女性血红蛋白水平低于12 g dl-1,也与疟疾诊断显著相关。讨论。本研究强调了血液学异常作为输入性疟疾病例关键诊断指标的重要性。通过分析回顾性数据,我们观察到这些异常,特别是血小板减少症和贫血,在确认患有疟疾的返回旅行者中很常见。这些发现表明,临床医生可以将这些标记物作为早期疟疾诊断的一种有价值的工具,从而有可能改善患者的预后。此外,该研究还强调,有必要提高非流行地区医疗保健提供者对旅行者中出现疟疾的认识。结论。血液学参数,如血小板减少症、淋巴细胞减少症和贫血症,是回国旅行者疟疾的宝贵诊断工具。这些发现表明,应将这些参数纳入诊断方案,以提高疟疾诊断的准确性和及时性,特别是在无法获得先进诊断工具的临床环境中。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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