Hypereosinophilia in Children.

IF 5.4 2区医学 Q1 ALLERGY

Current Allergy and Asthma Reports Pub Date : 2025-05-23 DOI:10.1007/s11882-025-01205-w

Tyesha Coleman, Richard Bickel, John Noel, Kathleen R May

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引用次数: 0

Abstract

Purpose of review: Hypereosinophilia is defined as an absolute eosinophil count greater than 1500 cells/mm3. This is a condition often observed in the pediatric population, with benign/self-resolving to life-threatening etiologies. Identifying the cause of hypereosinophilia can be challenging, given its broad associated differential diagnosis and diversity of presentations. This review provides an overview of eosinophil biology and explores causes of hypereosinophilia in children, emphasizing diagnostic and therapeutic challenges, while underscoring the importance of recognizing rare causes including primary hypereosinophilic syndrome (HES).

Recent findings: Classification of hypereosinophilic subtypes has evolved, as has understanding of etiologies with advances in modern diagnostic tools. Newer therapeutic options with low side-effect profiles have expanded treatment options in patients with HES. Despite recent improvements in medical management, HES remains a serious medical condition with considerable morbidity and potential mortality. Early identification and appropriate treatment can improve prognosis and reduce the burden of disease in children.

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儿童嗜酸性粒细胞增多症。

综述目的：嗜酸性粒细胞增多被定义为绝对嗜酸性粒细胞计数大于1500细胞/mm3。这是一种常见于儿科人群的情况，具有良性/自愈到危及生命的病因。由于其广泛的相关鉴别诊断和表现的多样性，确定嗜酸性粒细胞增多症的原因可能具有挑战性。本文综述了嗜酸性粒细胞生物学的概况，探讨了儿童嗜酸性粒细胞增多的原因，强调了诊断和治疗方面的挑战，同时强调了认识罕见原因的重要性，包括原发性嗜酸性粒细胞增多综合征（HES）。最近发现：随着现代诊断工具的进步，对病因的理解也在不断发展，嗜酸性细胞增多症亚型的分类也在不断发展。副作用较低的新治疗方案扩大了HES患者的治疗选择。尽管最近医疗管理有所改善，但HES仍然是一种严重的疾病，发病率和潜在死亡率很高。早期发现和适当治疗可改善预后并减轻儿童的疾病负担。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Allergy and Asthma Reports 医学-过敏

CiteScore

11.20

自引率

1.80%

发文量

审稿时长

6-12 weeks

期刊介绍： The aim of Current Allergy and Asthma Reports is to systematically provide the views of highly selected experts on current advances in the fields of allergy and asthma and highlight the most important papers recently published. All reviews are intended to facilitate the understanding of new advances in science for better diagnosis, treatment, and prevention of allergy and asthma. We accomplish this aim by appointing international experts in major subject areas across the discipline to review select topics emphasizing recent developments and highlighting important new papers and emerging concepts. We also provide commentaries from well-known figures in the field, and an Editorial Board of internationally diverse members suggests topics of special interest to their country/region and ensures that topics are current and include emerging research. Over a one- to two-year period, readers are updated on all the major advances in allergy and asthma.