Morbidity and Mortality Associated With Systemic Lupus Erythematosus and Retinal Vasculitis: A Multicenter Cohort Study.

IF 0.9 4区医学 Q4 OPHTHALMOLOGY

Ophthalmic surgery, lasers & imaging retina Pub Date : 2025-05-23 DOI:10.3928/23258160-20250417-01

Jennifer D Huang, Kapil Mishra, Karen Wai, Prithvi Mruthyunjaya, Ehsan Rahimy

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引用次数: 0

Abstract

Background and objective: To determine the long-term rates of death, myocardial infarction (MI), dialysis, and stroke in patients with systemic lupus erythematosus (SLE) and retinal vasculitis (RV).

Patients and methods: A total of 435 patients with SLE/RV were identified using TriNetX, a federated electronic health records network from January 1, 2004 to January 1, 2024. Patients were matched for age, sex, race, and propensity score, excluding those with MI, dialysis, or cerebrovascular complication in the year prior to diagnosis.

Results: The risk of death, MI, and dialysis was not statistically different between cohorts at 5 and 10 years. The risk of stroke was increased at 5 and 10 years in the SLE/RV cohort, but no statistically significant difference in risk was found at 1 year.

Conclusion: Although patients with and without RV may have similar long-term rates of death, MI, and dialysis, patients with SLE/RV may have an elevated risk of stroke in the subsequent 5 and 10 years after diagnosis, highlighting the need for multidisciplinary care. [Ophthalmic Surg Lasers Imaging Retina 2025;56:XX-XX.].

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系统性红斑狼疮和视网膜血管炎相关的发病率和死亡率：一项多中心队列研究。

背景和目的：确定系统性红斑狼疮（SLE）和视网膜血管炎（RV）患者的长期死亡率、心肌梗死（MI）、透析和卒中发生率。患者和方法：从2004年1月1日到2024年1月1日，共有435名SLE/RV患者通过TriNetX（联邦电子健康记录网络）进行了识别。患者根据年龄、性别、种族和倾向评分进行匹配，排除诊断前一年患有心肌梗死、透析或脑血管并发症的患者。结果：在5年和10年的队列中，死亡、心肌梗死和透析的风险无统计学差异。在SLE/RV队列中，卒中的风险在5年和10年时增加，但在1年时没有发现统计学上的显著差异。结论：尽管患有和不患有RV的患者可能具有相似的长期死亡率、心肌梗死和透析率，但SLE/RV患者在诊断后的5年和10年内卒中风险可能升高，这突出了多学科治疗的必要性。[眼科外科激光成像视网膜2025；56:XX-XX]。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Ophthalmic surgery, lasers & imaging retina OPHTHALMOLOGY-SURGERY

CiteScore

1.80

自引率

0.00%

发文量

期刊介绍： OSLI Retina focuses exclusively on retinal diseases, surgery and pharmacotherapy. OSLI Retina will offer an expedited submission to publication effort of peer-reviewed clinical science and case report articles. The front of the journal offers practical clinical and practice management features and columns specific to retina specialists. In sum, readers will find important peer-reviewed retina articles and the latest findings in techniques and science, as well as informative business and practice management features in one journal.