Correlation Analysis between Serum NLRP1 Inflammasome and Depression in Acute Stage of Stroke.

IF 2.4 4区医学 Q3 ENDOCRINOLOGY & METABOLISM

Neuroimmunomodulation Pub Date : 2025-01-01 Epub Date: 2025-05-22 DOI:10.1159/000546439

Song Li, Kun Geng, Lin Yang, Yaling Zhang, Xiaoyang Tao, Jierui Cai, Linyang Li, Zemin Luo, Birendra Mahato, Yonglei Liu, Xiaoling Yin, Hiu Cai, Jishuai Zhao, Heyan Chen, Lixia Wang

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引用次数: 0

Abstract

Introduction: The aim of this study was to investigate the correlation between serum NLRP1 inflammasome level and depressive state in acute stage of stroke.

Methods: A total of 102 patients with acute stroke who were hospitalized for the first time in the Department of Neurology of the First Affiliated Hospital of Dali University from April 2023 to October 2023 were included, and 80 of them met the inclusion criteria. On the 7th day of admission, the patients were evaluated using the 24-item Hamilton Depression Scale (HAMD-24) and were divided into 31 patients in the acute stage of stroke depression group and 49 patients in the acute stage of stroke non-depression group. The general clinical data of patients were collected, the unified Stroke Scale score (NIHSS) and Pittsburgh Sleep Quality Index score (PSQI) were performed, and fasting serum was collected at 8 a.m. the next morning. NLRP1 inflammatory bodies (NLRP1, ASC, Caspase1) and inflammatory factors IL-1β, IL-18, IL-10, tumor necrosis factor (TNF)-α were detected.

Results: (1) The incidence of depression in acute stage of stroke was 38.75%. (2) There were statistically significant differences in PSQI and NIHSS scores between the two groups (p < 0.05), and the scores were correlated with the degree of depression, and were positively correlated with HAMD-24 scores (p < 0.05). (3) The expression levels of NLRP1, IL-18, and TNF-α in serum were significantly different between the two groups (p < 0.01), and the expression levels were correlated with the degree of depression, and were positively correlated with HAMD-24 scores (p < 0.05). There were no significant differences in the expression levels of serum IL-1β, IL-10, Caspase-1 and ASC (p > 0.05). (4) Further analysis by stepwise fitting binary logistic regression showed that NIHSS score, NLRP1, and IL-18 level were independent risk factors for depression in acute stage of stroke (p < 0.05). (5) NIIHSS score, NLRP1, and IL-18 receiver operating characteristic curve area have certain predictive value for the occurrence and development of acute depression during stroke.

Conclusion: The more severe the neurological impairment and sleep disorder, the higher the expression level of NLRP1 inflammasome in blood, and the more severe the depression in acute stage of stroke.

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脑卒中急性期血清NLRP1炎性体与抑郁的相关性分析。

目的：探讨脑卒中急性期血清NLRP1炎性体水平与抑郁状态的关系。方法：选取大理大学第一附属医院神经内科于2023年4月至2023年10月首次住院的急性脑卒中患者102例，其中符合纳入标准的患者80例。入院第7天采用24项汉密尔顿抑郁量表（HAMD-24）对患者进行评估，并将患者分为卒中急性期抑郁组31例和卒中急性期非抑郁组49例。收集患者一般临床资料，进行统一脑卒中量表评分（NIHSS）和匹兹堡睡眠质量指数评分（PSQI），并于次日清晨采集空腹血清。检测NLRP1炎性体（NLRP1、ASC、Caspase1）及炎性因子IL-1β、IL-18、IL-10、TNF-α。结果:1。脑卒中急性期抑郁发生率为38.75%。2. 两组患者PSQI、NIHSS评分差异有统计学意义（P < 0.05），且与抑郁程度呈正相关，与HAMD-24评分呈正相关（P < 0.05）。3. 两组患者血清中NLRP1、IL-18、TNF-α的表达水平差异有统计学意义（P < 0.01），且表达水平与抑郁程度相关，与HAMD-24评分呈正相关（P < 0.05）。血清IL-1β、IL-10、Caspase-1和ASC表达水平差异无统计学意义（P < 0.05）。4. 进一步逐步拟合logistic回归分析显示，NIHSS评分、NLRP1、IL-18水平是脑卒中急性期抑郁的独立危险因素（P < 0.05）。5. NIIHSS评分、NLRP1、IL-18 ROC曲线面积对脑卒中急性抑郁的发生发展有一定的预测价值。结论：脑卒中急性期神经功能损害和睡眠障碍越严重，NLRP1炎性体在血液中的表达水平越高，抑郁程度越严重。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neuroimmunomodulation 医学-免疫学

CiteScore

3.60

自引率

4.20%

发文量

审稿时长

>12 weeks

期刊介绍： The rapidly expanding area of research known as neuroimmunomodulation explores the way in which the nervous system interacts with the immune system via neural, hormonal, and paracrine actions. Encompassing both basic and clinical research, ''Neuroimmunomodulation'' reports on all aspects of these interactions. Basic investigations consider all neural and humoral networks from molecular genetics through cell regulation to integrative systems of the body. The journal also aims to clarify the basic mechanisms involved in the pathogenesis of the CNS pathology in AIDS patients and in various neurodegenerative diseases. Although primarily devoted to research articles, timely reviews are published on a regular basis.