(±)-Rhodaulision A and B, two pairs of meroterpenoids from branches and leaves of Rhododendron dauricum L. and their anti-osteoarthritis activity.

IF 1.9 3区化学 Q3 CHEMISTRY, APPLIED

Natural Product Research Pub Date : 2025-05-23 DOI:10.1080/14786419.2025.2509297

Bei Wang, Wei Liu, Qiming Lu, Liang Xiang

引用次数: 0

Abstract

Two pairs of meroterpenoids, (±)-rhodaulision A (1) and B (2) and 8 known compounds [2,7-dimethyl-2-(4-methylpent-3-enyl)-2-chromen-5-ol (3), cannabiorcichromenic acid (4), ranhuadujuanine C (5), ranhuadujuanine D (6), grifolin (7), ilicicolinic acid B (8), anthoponoid H (9), and anthoponoid I (10)] were isolated and identified from the dichloromethane extracts of Rhododendron dauricum L. Meanwhile, extensive spectroscopic methods, NMR and ECD calculations, as well as MS analysis were employed to elucidate the structures of 1 and 2. Subsequently, compounds 1-10 exhibited a powerful inhibition of osteoclast genesis with an in vitro ratio of more than 90% at 10 μM.

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（±）-杜鹃花（rhodaulision） A和B，从杜鹃花枝叶中提取的两对萜类化合物及其抗骨关节炎活性。

两双meroterpenoids(±)-rhodaulision A(1)和(2)和8个已知化合物(2,7-dimethyl-2——(4-methylpent-3-enyl) 2-chromen-5-ol (3), cannabiorcichromenic酸(4)、ranhuadujuanine C (5), ranhuadujuanine D (6), grifolin (7), ilicicolinic酸B (8), anthoponoid H(9),我anthoponoid(10)]的二氯甲烷提取分离和识别杜鹃dauricum l .与此同时,广泛的光谱方法,核磁共振和儿童早期开发的计算,利用质谱分析对1和2的结构进行了分析。随后，化合物1-10在10 μM下表现出对破骨细胞形成的强大抑制作用，体外抑制率超过90%。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Natural Product Research 化学-医药化学

CiteScore

5.10

自引率

9.10%

发文量

605

审稿时长

2.1 months

期刊介绍： The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds. The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal. Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section. All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.