Expression of miRNAs in the Relationship Between Periodontitis and Cardiovascular Diseases: A Systematic Review.

IF 3.6 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Non-Coding RNA Pub Date : 2025-05-06 DOI:10.3390/ncrna11030037

Montiel Guerrero-Sabater, María Cosín-Villanueva, Pedro Almiñana-Pastor, Andrés López-Roldán

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引用次数: 0

Abstract

Objectives: Periodontitis is a chronic inflammatory disease that could influence the pathophysiology of cardiovascular diseases through immunoinflammatory and epigenetic mechanisms. MicroRNAs (miRNAs) could be key mediators in this interaction, regulating gene expression and the synthesis of inflammatory molecules. The objective of this systematic review was to evaluate the relationship between periodontitis and cardiovascular diseases by analyzing the expression of miRNAs involved in both pathologies.

Methods: A systematic search was performed in the PubMed, Scopus, Embase, and Web of Science databases following the PRISMA guidelines. A total of 320 studies were identified, of which seven were included after applying eligibility criteria. Data on study design, sample characteristics, periodontal and cardiovascular diagnostic methodology, and the analyzed miRNAs were extracted.

Results: The included studies were observational case-control studies in humans (n = 5) and experimental studies in animal models (n = 3). The miRNAs selected by the studies to link both pathologies were miR-155, miR-155-5p, miR-146a, miR-143, miR-145, and miR-23b. Most studies observed the overexpression of these miRNAs in patients with periodontitis and cardiovascular disease, with miR-146a being the most frequently associated.

Conclusions: The findings suggest that certain miRNAs, particularly miR-146a, may play a key role in the connection between periodontitis and cardiovascular disease. Its overexpression in patients with both pathologies reinforces the hypothesis of its involvement in the inflammatory processes associated with both conditions. It would be interesting to conduct studies to validate their clinical applicability as biomarkers of susceptibility to cardiovascular disease.

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mirna在牙周炎与心血管疾病关系中的表达：系统综述。

目的：牙周炎是一种慢性炎症性疾病，可通过免疫炎症和表观遗传机制影响心血管疾病的病理生理。MicroRNAs （miRNAs）可能是这种相互作用的关键介质，调节基因表达和炎症分子的合成。本系统综述的目的是通过分析与牙周炎和心血管疾病相关的mirna的表达来评估牙周炎和心血管疾病之间的关系。方法：系统检索PubMed、Scopus、Embase和Web of Science数据库，遵循PRISMA指南。总共确定了320项研究，其中7项在应用资格标准后纳入。提取有关研究设计、样本特征、牙周和心血管诊断方法学以及分析的mirna的数据。结果：纳入的研究为人类观察性病例对照研究（n = 5）和动物模型实验研究（n = 3）。这些研究选择的连接这两种病理的mirna是miR-155、miR-155-5p、miR-146a、miR-143、miR-145和miR-23b。大多数研究观察到这些mirna在牙周炎和心血管疾病患者中过表达，其中miR-146a是最常见的相关mirna。结论：研究结果表明，某些mirna，特别是miR-146a，可能在牙周炎和心血管疾病之间的联系中发挥关键作用。它在两种病理患者中的过表达强化了它参与两种疾病相关的炎症过程的假设。开展研究以验证其作为心血管疾病易感性生物标志物的临床适用性将是一件有趣的事情。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Non-Coding RNA Biochemistry, Genetics and Molecular Biology-Genetics

CiteScore

6.70

自引率

4.70%

发文量

审稿时长

10 weeks

期刊介绍： Functional studies dealing with identification, structure-function relationships or biological activity of: small regulatory RNAs (miRNAs, siRNAs and piRNAs) associated with the RNA interference pathway small nuclear RNAs, small nucleolar and tRNAs derived small RNAs other types of small RNAs, such as those associated with splice junctions and transcription start sites long non-coding RNAs, including antisense RNAs, long ''intergenic'' RNAs, intronic RNAs and ''enhancer'' RNAs other classes of RNAs such as vault RNAs, scaRNAs, circular RNAs, 7SL RNAs, telomeric and centromeric RNAs regulatory functions of mRNAs and UTR-derived RNAs catalytic and allosteric (riboswitch) RNAs viral, transposon and repeat-derived RNAs bacterial regulatory RNAs, including CRISPR RNAS Analysis of RNA processing, RNA binding proteins, RNA signaling and RNA interaction pathways: DICER AGO, PIWI and PIWI-like proteins other classes of RNA binding and RNA transport proteins RNA interactions with chromatin-modifying complexes RNA interactions with DNA and other RNAs the role of RNA in the formation and function of specialized subnuclear organelles and other aspects of cell biology intercellular and intergenerational RNA signaling RNA processing structure-function relationships in RNA complexes RNA analyses, informatics, tools and technologies: transcriptomic analyses and technologies development of tools and technologies for RNA biology and therapeutics Translational studies involving long and short non-coding RNAs: identification of biomarkers development of new therapies involving microRNAs and other ncRNAs clinical studies involving microRNAs and other ncRNAs.