Predictors and prevalence of paradoxical hypertrichosis in alexandrite laser-based facial hair removal: results from a prospective clinical study.

IF 2.1 4区 医学 Q3 ENGINEERING, BIOMEDICAL
Hanadi Qeyam, Ameera Elrafi, Sohaib Alomari, Mohammad Jaradat
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引用次数: 0

Abstract

Objective: To investigate the prevalence and identify potential contributing factors of facial paradoxical hypertrichosis (PH) following long-pulse Alexandrite LHR among Jordanian women.

Methodology: This observational, prospective study included female patients aged sixteen and above undergoing long-pulse Alexandrite laser treatment for facial hair at the Dermatology Department of King Abdullah University Hospital, Irbid, Jordan, from March 2023 to December 2024. Data on patient demographics, treatment sessions, and contributing factors such as hormonal conditions, family history, and sunblock use were collected through patient questionnaires and medical records.

Results: The study revealed a prevalence of facial PH of 16.2%, significant associations were found with irregular menstrual cycles (33.3% vs. 12.6%, P = 0.001), family history of hirsutism (27.8% vs. 13.8%, P = 0.001), and Fitzpatrick skin types III and IV (27.1% and 21.9% respectively, P = 0.001). Multiple laser sessions (6-10) increased PH risk (30.9% vs. 6.8%, P = 0.001), as did PCOS (33.3% vs. 14.1%, P < 0.001). Regular sunblock use demonstrated a protective effect (12.1% vs. 36.1%, P = 0.001). OCP use showed no significant association with PH (13.8% vs. 17.6%, P = 0.19).

Conclusion: Our findings highlight a higher-than-reported prevalence of PH following Alexandrite laser hair removal, key risk factors include PCOS, menstrual irregularities, darker skin types, and lack of sun protection. Understanding these associations can help clinicians take preventive measures, optimize patient selection, and provide better counseling to reduce the risk of paradoxical hypertrichosis and improve treatment outcomes.

Clinical trial registration: Not applicable.

预测因素和患病率的矛盾多毛在亚历山大变石激光面部毛发去除:结果从前瞻性临床研究。
目的:调查约旦妇女长脉冲亚历山大石LHR后面部反常多毛症(PH)的患病率并确定潜在的影响因素。方法:这项观察性前瞻性研究纳入了2023年3月至2024年12月在约旦伊尔比德阿卜杜拉国王大学医院皮肤科接受长脉冲亚历山大变石激光治疗面部毛发的16岁及以上女性患者。通过患者问卷调查和医疗记录收集患者人口统计数据、治疗时间以及荷尔蒙状况、家族史和防晒霜使用等影响因素。结果:研究显示面部PH值的患病率为16.2%,月经周期不规律(33.3%对12.6%,P = 0.001),多毛家族史(27.8%对13.8%,P = 0.001)和Fitzpatrick皮肤III型和IV型(分别为27.1%和21.9%,P = 0.001)有显著相关性。多次激光脱毛(6-10次)会增加PH风险(30.9% vs. 6.8%, P = 0.001), PCOS (33.3% vs. 14.1%)也会增加PH风险。结论:我们的研究结果突出了紫翠石激光脱毛后PH的患病率高于报道,主要危险因素包括PCOS、月经不规律、肤色较深和缺乏防晒。了解这些关联可以帮助临床医生采取预防措施,优化患者选择,并提供更好的咨询,以减少悖论性多毛的风险,提高治疗效果。临床试验注册:不适用。
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来源期刊
Lasers in Medical Science
Lasers in Medical Science 医学-工程:生物医学
CiteScore
4.50
自引率
4.80%
发文量
192
审稿时长
3-8 weeks
期刊介绍: Lasers in Medical Science (LIMS) has established itself as the leading international journal in the rapidly expanding field of medical and dental applications of lasers and light. It provides a forum for the publication of papers on the technical, experimental, and clinical aspects of the use of medical lasers, including lasers in surgery, endoscopy, angioplasty, hyperthermia of tumors, and photodynamic therapy. In addition to medical laser applications, LIMS presents high-quality manuscripts on a wide range of dental topics, including aesthetic dentistry, endodontics, orthodontics, and prosthodontics. The journal publishes articles on the medical and dental applications of novel laser technologies, light delivery systems, sensors to monitor laser effects, basic laser-tissue interactions, and the modeling of laser-tissue interactions. Beyond laser applications, LIMS features articles relating to the use of non-laser light-tissue interactions.
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