{"title":"Interaction Between Age and Task Demand on Brain Connectivity Associated With Mastication.","authors":"Chia-Shu Lin, Wei-Chieh Kao","doi":"10.1111/joor.14036","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Sensorimotor processing is critical to the ageing brain and geriatric health. Masticatory performance (MP) is key to the systemic health of older individuals. Neuroimaging research has revealed a potential link between brain functional connectivity (FC) and MP. Using the masticatory perturbation task (MPT), we investigated the FC associated with MP under different conditions of task demand and age groups.</p><p><strong>Methods: </strong>Thirty-four older-age (OA, ≥ 65 years), 26 middle-aged (MA, between 40 and 64 years) and 42 younger-age (YA, < 40 years) participants were recruited for assessment of the MPT, and structural and resting-state (rs) functional magnetic resonance imaging (MRI). Analyses of seed-based connectivity and FC networks were conducted to investigate the rs-FC associated with MP in the baseline condition (without perturbation) and the perturbation condition (with perturbation) of MPT.</p><p><strong>Results: </strong>(A) In the baseline condition, OA participants with better MP showed higher rs-FC between the cerebellum and primary sensorimotor cortices. (B) In the perturbation condition, OA participants with better MP showed higher rs-FC between the middle frontal gyrus and the primary somatosensory cortex, and MA participants with better MP showed higher rs-FC between the supplementary motor area and the caudate nucleus. (C) The network analysis revealed that the pattern of rs-FC related to MP differed between age groups and task conditions. In the perturbation condition, YA participants with better MP showed higher rs-FC outside the sensorimotor network.</p><p><strong>Conclusion: </strong>The findings provide novel evidence demonstrating an interaction between age and task demand on rs-FC associated with MP.</p>","PeriodicalId":16605,"journal":{"name":"Journal of oral rehabilitation","volume":" ","pages":""},"PeriodicalIF":3.1000,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of oral rehabilitation","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1111/joor.14036","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"DENTISTRY, ORAL SURGERY & MEDICINE","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Sensorimotor processing is critical to the ageing brain and geriatric health. Masticatory performance (MP) is key to the systemic health of older individuals. Neuroimaging research has revealed a potential link between brain functional connectivity (FC) and MP. Using the masticatory perturbation task (MPT), we investigated the FC associated with MP under different conditions of task demand and age groups.
Methods: Thirty-four older-age (OA, ≥ 65 years), 26 middle-aged (MA, between 40 and 64 years) and 42 younger-age (YA, < 40 years) participants were recruited for assessment of the MPT, and structural and resting-state (rs) functional magnetic resonance imaging (MRI). Analyses of seed-based connectivity and FC networks were conducted to investigate the rs-FC associated with MP in the baseline condition (without perturbation) and the perturbation condition (with perturbation) of MPT.
Results: (A) In the baseline condition, OA participants with better MP showed higher rs-FC between the cerebellum and primary sensorimotor cortices. (B) In the perturbation condition, OA participants with better MP showed higher rs-FC between the middle frontal gyrus and the primary somatosensory cortex, and MA participants with better MP showed higher rs-FC between the supplementary motor area and the caudate nucleus. (C) The network analysis revealed that the pattern of rs-FC related to MP differed between age groups and task conditions. In the perturbation condition, YA participants with better MP showed higher rs-FC outside the sensorimotor network.
Conclusion: The findings provide novel evidence demonstrating an interaction between age and task demand on rs-FC associated with MP.
期刊介绍：
Journal of Oral Rehabilitation aims to be the most prestigious journal of dental research within all aspects of oral rehabilitation and applied oral physiology. It covers all diagnostic and clinical management aspects necessary to re-establish a subjective and objective harmonious oral function.
Oral rehabilitation may become necessary as a result of developmental or acquired disturbances in the orofacial region, orofacial traumas, or a variety of dental and oral diseases (primarily dental caries and periodontal diseases) and orofacial pain conditions. As such, oral rehabilitation in the twenty-first century is a matter of skilful diagnosis and minimal, appropriate intervention, the nature of which is intimately linked to a profound knowledge of oral physiology, oral biology, and dental and oral pathology.
The scientific content of the journal therefore strives to reflect the best of evidence-based clinical dentistry. Modern clinical management should be based on solid scientific evidence gathered about diagnostic procedures and the properties and efficacy of the chosen intervention (e.g. material science, biological, toxicological, pharmacological or psychological aspects). The content of the journal also reflects documentation of the possible side-effects of rehabilitation, and includes prognostic perspectives of the treatment modalities chosen.
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