Optimizing outcomes of partial nephrectomy in patients with tumors in solitary kidneys: a non-systematic review.

Q3 Medicine

Journal of Medicine and Life Pub Date : 2025-04-01 DOI:10.25122/jml-2025-0066

Stelian Ianiotescu, Constantin Gingu, Alexandru Iordache, Adrian Preda, Osama Salloum, Irina Balescu, Nicolae Bacalbasa, Ioanel Sinescu

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引用次数: 0

Abstract

This review consolidates recent evidence on managing renal cell carcinoma (RCC) in patients with solitary kidneys. It provides a comprehensive discussion of evolving strategies in partial nephrectomy-including open, laparoscopic, and particularly robot-assisted partial nephrectomy (RAPN)-along with thermal and advanced ablative therapies, non-surgical options (such as stereotactic ablative body radiotherapy [SABR] and active surveillance [AS]), and emerging neoadjuvant systemic treatments with tyrosine kinase inhibitors (TKIs) and immune checkpoint inhibitors (ICIs). In addition, the integration of artificial intelligence (AI) for preoperative planning, intraoperative guidance, and postoperative outcome prediction is discussed. Given the limited renal reserve in these patients, preserving functional renal parenchyma is paramount. This multidisciplinary review synthesizes evidence from 2018 to the present and is supported by 70 contemporary references.

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孤立肾肿瘤患者部分肾切除术的最佳预后：一项非系统综述。

这篇综述巩固了最近关于孤立肾患者肾细胞癌（RCC）治疗的证据。它全面讨论了部分肾切除术的发展策略，包括开放，腹腔镜，特别是机器人辅助部分肾切除术（RAPN），以及热和先进的消融治疗，非手术选择（如立体定向消融体放疗[SABR]和主动监测[as]），以及新兴的新辅助全身治疗酪氨酸激酶抑制剂（TKIs）和免疫检查点抑制剂（ICIs）。此外，还讨论了人工智能（AI）在术前规划、术中指导和术后预后预测中的集成。鉴于这些患者的肾储备有限，保留功能性肾实质是至关重要的。这一多学科综述综合了2018年至今的证据，并得到了70篇当代参考文献的支持。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Medicine and Life Medicine-Medicine (all)

CiteScore

1.90

自引率

0.00%

发文量

202

期刊介绍： The Journal of Medicine and Life publishes peer-reviewed articles from various fields of medicine and life sciences, including original research, systematic reviews, special reports, case presentations, major medical breakthroughs and letters to the editor. The Journal focuses on current matters that lie at the intersection of biomedical science and clinical practice and strives to present this information to inform health care delivery and improve patient outcomes. Papers addressing topics such as neuroprotection, neurorehabilitation, neuroplasticity, and neuroregeneration are particularly encouraged, as part of the Journal''s continuous interest in neuroscience research. The Editorial Board of the Journal of Medicine and Life is open to consider manuscripts from all levels of research and areas of biological sciences, including fundamental, experimental or clinical research and matters of public health. As part of our pledge to promote an educational and community-building environment, our issues feature sections designated to informing our readers regarding exciting international congresses, teaching courses and relevant institutional-level events.