The Role of Serum Testosterone in the Pathogenesis and Treatment of Prostate Cancer: A Review Based on the Clinical Evidence.

IF 1.8 3区医学 Q3 UROLOGY & NEPHROLOGY

International Journal of Urology Pub Date : 2025-05-23 DOI:10.1111/iju.70125

Xue Zhao, Shinichi Sakamoto, Yasutaka Yamada, Kodai Sato, Takaaki Tamura, Hiroki Shibata, Tomokazu Sazuka, Yusuke Imamura, Tomohiko Ichikawa

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引用次数: 0

Abstract

Serum testosterone plays a pivotal role in the pathogenesis and treatment of prostate cancer, influencing tumor growth and progression. This review synthesizes current clinical evidence on the dual role of serum testosterone as both a biomarker of carcinogenesis and a target for therapeutic intervention. We discuss the mechanisms linking androgen signaling to prostate cancer development, emphasizing the role of testosterone in androgen receptor activation and cellular proliferation. Furthermore, we explore the clinical implications of testosterone suppression strategies, including androgen deprivation therapy (ADT) and bipolar androgen therapy (BAT), highlighting their impact on patient outcomes. Emerging evidence on the prognostic significance of nadir testosterone levels, testosterone rebound, and treatment resistance is also analyzed. Finally, we address the challenges and opportunities in testosterone monitoring, aiming to enhance precision medicine approaches for managing prostate cancer. This review underscores the importance of personalized testosterone-based strategies to optimize therapeutic outcomes and improve patient quality of life.

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血清睾酮在前列腺癌发病和治疗中的作用：基于临床证据的综述。

血清睾酮在前列腺癌的发病和治疗中起关键作用，影响肿瘤的生长和进展。这篇综述综合了目前关于血清睾酮作为致癌生物标志物和治疗干预靶点的双重作用的临床证据。我们讨论了雄激素信号与前列腺癌发展的联系机制，强调睾酮在雄激素受体激活和细胞增殖中的作用。此外，我们探讨了睾酮抑制策略的临床意义，包括雄激素剥夺疗法（ADT）和双相雄激素疗法（BAT），强调了它们对患者预后的影响。新证据的预后意义的最低点睾酮水平，睾酮反弹和治疗抵抗也进行了分析。最后，我们讨论了睾酮监测的挑战和机遇，旨在提高前列腺癌治疗的精准医学方法。本综述强调了个性化睾酮治疗策略对优化治疗结果和提高患者生活质量的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Urology 医学-泌尿学与肾脏学

CiteScore

4.70

自引率

11.50%

发文量

340

审稿时长

3 months

期刊介绍： International Journal of Urology is the official English language journal of the Japanese Urological Association, publishing articles of scientific excellence in urology. Submissions of papers from all countries are considered for publication. All manuscripts are subject to peer review and are judged on the basis of their contribution of original data and ideas or interpretation.