High prevalence of hyperuricemia and its risk factors in a Chinese cohort of primary hyperparathyroidism patients.

IF 3.7 3区医学 Q2 Medicine

Endocrine Pub Date : 2025-05-23 DOI:10.1007/s12020-025-04276-x

Runxue Yuan, An Song, Yun Zhang, Yue Sha, Ou Wang, Yan Jiang, Mei Li, Weibo Xia, Xuejun Zeng, Xiaoping Xing

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引用次数: 0

Abstract

Purpose: Primary hyperparathyroidism (PHPT) is characterized by autonomous and excessive parathyroid hormone (PTH) secretion due to parathyroid gland lesions. Patients can be complicated with hyperuricemia (HUA), however, data about HUA in Chinese PHPT patients are lacking. This study aimed to explore the prevalence of HUA, factors influencing serum uric acid (SUA) level and the impacts of parathyroidectomy (PTX).

Methods: 328 inpatients diagnosed with PHPT were included in total. Clinical data were collected and compared between HUA and non-HUA group. Multivariate linear regression was used to explore the factors affecting preoperative SUA and its variation after PTX. The impacts of SUA on bone mineral density (BMD) under different models were also analyzed.

Results: The prevalence of HUA in PHPT patients was nearly 32%. Compared with non-HUA group, HUA group had significantly higher serum calcium (Ca) (2.92 [2.75, 3.26] vs. 2.78 [2.62, 3.03] mmol/L, P < 0.001), while PTH increased without significance. Gender, body mass index, serum Ca, triglycerides and renal function were independently associated with SUA. SUA decreased after PTX (340.00 [291.50, 421.00] vs. 315.00 [270.50, 375.00] μmol/L, P = 0.018), with change of SUA significantly associating with changes in serum Ca and phosphate. Presurgical SUA was positively related with femoral neck, total hip and lumbar spine BMDs after adjusting for confounders.

Conclusion: A relatively high proportion of HUA was found in our study. Besides the common risk factors, hypercalcemia may contribute to the increased SUA in PHPT patients, which could be significantly improved by curative PTX. SUA might have a protective effect on bone loss in PHPT patients.

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中国原发性甲状旁腺功能亢进患者高尿酸血症的高发率及其危险因素

目的：原发性甲状旁腺功能亢进（PHPT）以甲状旁腺病变引起的甲状旁腺激素（PTH）自主分泌过多为特征。患者可能并发高尿酸血症（HUA），然而，关于中国PHPT患者HUA的数据缺乏。本研究旨在探讨HUA的患病率、血清尿酸（SUA）水平的影响因素以及甲状旁腺切除术（PTX）的影响。方法：共纳入328例确诊为PHPT的住院患者。收集HUA组与非HUA组的临床资料进行比较。采用多元线性回归分析术前SUA的影响因素及PTX术后SUA的变化。分析了不同模型下SUA对骨密度的影响。结果：PHPT患者HUA患病率近32%。与非HUA组相比，HUA组血清钙（Ca）明显升高(2.92 [2.75,3.26]vs. 2.78 [2.62, 3.03] mmol/L， P。除了常见的危险因素外，高钙血症也可能导致PHPT患者SUA升高，而治疗性PTX可显著改善SUA升高。SUA可能对PHPT患者骨质流失有保护作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Endocrine 医学-内分泌学与代谢

CiteScore

6.40

自引率

5.40%

发文量

期刊介绍： Well-established as a major journal in today’s rapidly advancing experimental and clinical research areas, Endocrine publishes original articles devoted to basic (including molecular, cellular and physiological studies), translational and clinical research in all the different fields of endocrinology and metabolism. Articles will be accepted based on peer-reviews, priority, and editorial decision. Invited reviews, mini-reviews and viewpoints on relevant pathophysiological and clinical topics, as well as Editorials on articles appearing in the Journal, are published. Unsolicited Editorials will be evaluated by the editorial team. Outcomes of scientific meetings, as well as guidelines and position statements, may be submitted. The Journal also considers special feature articles in the field of endocrine genetics and epigenetics, as well as articles devoted to novel methods and techniques in endocrinology. Endocrine covers controversial, clinical endocrine issues. Meta-analyses on endocrine and metabolic topics are also accepted. Descriptions of single clinical cases and/or small patients studies are not published unless of exceptional interest. However, reports of novel imaging studies and endocrine side effects in single patients may be considered. Research letters and letters to the editor related or unrelated to recently published articles can be submitted. Endocrine covers leading topics in endocrinology such as neuroendocrinology, pituitary and hypothalamic peptides, thyroid physiological and clinical aspects, bone and mineral metabolism and osteoporosis, obesity, lipid and energy metabolism and food intake control, insulin, Type 1 and Type 2 diabetes, hormones of male and female reproduction, adrenal diseases pediatric and geriatric endocrinology, endocrine hypertension and endocrine oncology.