Impact of Bacillus coagulans ATCC7050 supplementation on growth, gut microbiota, and immunity in rainbow trout exposed to pretilachlor.

IF 1.9 4区医学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Drug and Chemical Toxicology Pub Date : 2025-05-23 DOI:10.1080/01480545.2025.2503942

Mahdieh Raeeszadeh, Reyhaneh Rezaeishoorijeh, Hamed Ghafarifarsani, Caterina Faggio

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引用次数: 0

Abstract

This study investigates the effects of Bacillus coagulans ATCC7050 probiotic supplementation on the growth performance, immune function, antioxidant activity, and liver health of rainbow trout (Oncorhynchus mykiss) exposed to the herbicide pretilachlor. Over 30 days, the fish were fed diets supplemented with B. coagulans (1 × 10⁶ or 1 × 10⁸ CFU/g) and/or 12.5% pretilachlor. Probiotic supplementation significantly enhanced growth parameters and reduced the feed conversion ratio, whereas herbicide exposure had the opposite effect (p = 0.000). Immune responses, including lysozyme activity and total immunoglobulin levels, were improved by probiotic treatment but suppressed by pretilachlor exposure (p = 0.001). Additionally, the probiotic increased antioxidant enzyme activity and reduced markers of oxidative stress. Liver function indicators elevated due to herbicide exposure were mitigated by B. coagulans supplementation (p = 0.028). These findings underscore the potential of B. coagulans to counteract herbicide-induced toxicity, supporting fish health and promoting more sustainable aquaculture practices.

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添加凝固芽孢杆菌ATCC7050对暴露于苯甲酰的虹鳟生长、肠道微生物群和免疫力的影响。

本研究探讨了添加凝固芽孢杆菌ATCC7050益生菌对暴露于除草剂苯甲草胺的虹鳟（Oncorhynchus mykiss）生长性能、免疫功能、抗氧化活性和肝脏健康的影响。30 d后，分别饲喂在饲料中添加凝固芽胞杆菌（1 × 106或1 × 108 CFU/g）和/或12.5%培草胺的饲料。添加益生菌显著提高了生长参数，降低了饲料系数，而除草剂则相反（p = 0.000）。免疫反应，包括溶菌酶活性和总免疫球蛋白水平，在益生菌处理下得到改善，但在暴露于苯胺后受到抑制（p = 0.001）。此外，益生菌提高了抗氧化酶活性，降低了氧化应激标志物。由于除草剂暴露导致的肝功能指标升高在补充B.凝固菌后得到缓解（p = 0.028）。这些发现强调了凝结芽藻在对抗除草剂毒性、支持鱼类健康和促进更可持续的水产养殖实践方面的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Drug and Chemical Toxicology 医学-毒理学

CiteScore

6.00

自引率

3.80%

发文量

审稿时长

3 months

期刊介绍： Drug and Chemical Toxicology publishes full-length research papers, review articles and short communications that encompass a broad spectrum of toxicological data surrounding risk assessment and harmful exposure. Manuscripts are considered according to their relevance to the journal. Topics include both descriptive and mechanics research that illustrates the risk assessment implications of exposure to toxic agents. Examples of suitable topics include toxicological studies, which are structural examinations on the effects of dose, metabolism, and statistical or mechanism-based approaches to risk assessment. New findings and methods, along with safety evaluations, are also acceptable. Special issues may be reserved to publish symposium summaries, reviews in toxicology, and overviews of the practical interpretation and application of toxicological data.