The use of DBS in the treatment of childhood cerebral palsy: a systematic review.

IF 1.3 4区医学 Q4 CLINICAL NEUROLOGY

Child's Nervous System Pub Date : 2025-05-23 DOI:10.1007/s00381-025-06852-y

Marcelo Anchieta Rohde, Rhaná Carolina Santos, Rafaela Jucá Lindner, Cristiano Mendes Ribeiro, Caroline Saldanha Custódio, Fernando Vélez Feijó, Amauri Dalla Corte

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引用次数: 0

Abstract

Purpose: To evaluate the efficacy and safety of DBS as a therapeutic intervention for managing motor symptoms and improving quality of life in patients with CP.

Methods: A systematic review was conducted following PRISMA guidelines. Studies were selected from PubMed, SCIELO, and the Regional Portal of BVS using defined inclusion criteria, assessing DBS outcomes on motor function, quality of life, and adverse events. The GRADE system evaluated the risk of bias.

Results: Of the 11 studies reviewed, 107 patients aged 5 to 26 years were included. Most studies focused on bilateral GPi stimulation, with nine reporting improvements in motor symptoms. However, outcomes varied, with significant benefits observed primarily in younger patients. Complications occurred in 22.4% of patients, predominantly infections and device-related issues.

Conclusion: This review showed that GPi DBS can improve motor symptoms and reduce disability in patients with CP, although outcomes are variable and influenced by patient characteristics, such as age. Further large-scale longitudinal studies are necessary to optimize candidate selection and enhance long-term outcomes.

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DBS在儿童脑瘫治疗中的应用：一项系统综述。

目的：评价DBS作为一种治疗性干预措施对控制cp患者运动症状和改善生活质量的有效性和安全性。方法：根据PRISMA指南进行系统评价。从PubMed、SCIELO和BVS区域门户网站中选择研究，使用定义的纳入标准，评估DBS在运动功能、生活质量和不良事件方面的结果。GRADE系统评估偏倚风险。结果：在回顾的11项研究中，包括107例5至26岁的患者。大多数研究集中在双侧GPi刺激上，其中9项报告了运动症状的改善。然而，结果各不相同，主要在年轻患者中观察到显著的益处。22.4%的患者出现并发症，主要是感染和器械相关问题。结论：本综述显示GPi DBS可以改善CP患者的运动症状并减少残疾，尽管结果是可变的，并且受患者特征（如年龄）的影响。进一步的大规模纵向研究是优化候选人选择和提高长期疗效的必要条件。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Child's Nervous System 医学-临床神经学

CiteScore

3.00

自引率

7.10%

发文量

322

审稿时长

3 months

期刊介绍： The journal has been expanded to encompass all aspects of pediatric neurosciences concerning the developmental and acquired abnormalities of the nervous system and its coverings, functional disorders, epilepsy, spasticity, basic and clinical neuro-oncology, rehabilitation and trauma. Global pediatric neurosurgery is an additional field of interest that will be considered for publication in the journal.