Evaluation of leptin and leptin receptor gene polymorphisms in bipolar disorder: focus on depressive episodes with atypical features.

IF 2.7 4区医学 Q3 ENDOCRINOLOGY & METABOLISM

Archives of Physiology and Biochemistry Pub Date : 2025-05-23 DOI:10.1080/13813455.2025.2507751

Hasan Mervan Aytac, Yasemin Oyaci, Eren Aytac, Mustafa Pehlivan, Furkan Bahadir Alptekin, Sacide Pehlivan

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引用次数: 0

Abstract

Objective: Our study aims to examine the effect of leptin (LEP) (-2548 G > A) (rs7799039) and leptin receptor (LEPR) (668 A > G) (rs1137101) gene polymorphisms on the etiopathogenesis of bipolar disorder (BD) by comparing them with a control group, as well as their association with depressive episodes featuring atypical symptoms.

Methods: The study included a sample of 103 individuals with BD and 103 healthy volunteers. Gene polymorphisms were identified from DNA samples through polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).

Results: The distribution of LEPR genotypes was significantly different between BD patients and healthy controls. Specifically, the homozygous LEPR GG genotype was more common in the control group than in BD patients. Additionally, genotype frequency distributions among BD patients varied significantly based on the presence of atypical depressive episodes. The LEPR AA and LEP GG genotypes were significantly more common among patients with a history of atypical depression. Logistic regression showed that the LEP polymorphism and Hamilton Depression Rating Scale (HAM-D) score predict atypical depression in BD.

Conclusion: In summary, while the LEPR polymorphism is linked to BD, the LEP polymorphism and symptom severity appear to predict atypical depressive episodes.

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双相情感障碍中瘦素和瘦素受体基因多态性的评估：关注具有非典型特征的抑郁发作。

目的：本研究旨在通过与对照组比较，探讨瘦素（LEP）（-2548 G > A）（rs7799039）和瘦素受体（LEPR）（668 A > G）（rs1137101）基因多态性在双相情感障碍（BD）发病中的作用，以及它们与非典型症状抑郁发作的关系。方法：研究包括103名双相障碍患者和103名健康志愿者。采用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）技术对DNA样品进行基因多态性鉴定。结果：LEPR基因型在BD患者和健康对照组之间的分布有显著差异。具体来说，纯合子LEPR GG基因型在对照组中比在BD患者中更常见。此外，基因型频率分布在双相障碍患者之间的差异显著基于非典型抑郁发作的存在。LEPR AA和LEP GG基因型在有非典型抑郁症病史的患者中更为常见。结论：综上所述，LEPR多态性与BD相关，而LEP多态性与症状严重程度可能预测非典型抑郁发作。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Archives of Physiology and Biochemistry ENDOCRINOLOGY & METABOLISM-PHYSIOLOGY

CiteScore

6.90

自引率

3.30%

发文量

期刊介绍： Archives of Physiology and Biochemistry: The Journal of Metabolic Diseases is an international peer-reviewed journal which has been relaunched to meet the increasing demand for integrated publication on molecular, biochemical and cellular aspects of metabolic diseases, as well as clinical and therapeutic strategies for their treatment. It publishes full-length original articles, rapid papers, reviews and mini-reviews on selected topics. It is the overall goal of the journal to disseminate novel approaches to an improved understanding of major metabolic disorders. The scope encompasses all topics related to the molecular and cellular pathophysiology of metabolic diseases like obesity, type 2 diabetes and the metabolic syndrome, and their associated complications. Clinical studies are considered as an integral part of the Journal and should be related to one of the following topics: -Dysregulation of hormone receptors and signal transduction -Contribution of gene variants and gene regulatory processes -Impairment of intermediary metabolism at the cellular level -Secretion and metabolism of peptides and other factors that mediate cellular crosstalk -Therapeutic strategies for managing metabolic diseases Special issues dedicated to topics in the field will be published regularly.