Role of hesperidin/hesperetin against chemotherapy-induced cardiotoxicity: a systematic review of non-clinical studies.

IF 6 2区 医学 Q1 ONCOLOGY
Sina Shaernejad, Ali Nosrat, Maryam Baeeri, Nasser Hashemi Goradel, Mirsalim SeyedSadeghi, Mostafa Akbariani, AmirAhmad Arabzadeh, Mahban Rahimifard, Hamed Haghi-Aminjan
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引用次数: 0

Abstract

Despite the undeniable role of chemotherapeutics in cancer treatment, their administration may be associated with various side effects. Cardiac injury is among the most crucial side effects related to the induction of chemotherapeutic agents. Since the heart is a vital organ, cardiotoxicity often prevents clinicians from continuing chemotherapy. Hesperidin and hesperetin, flavonoids derived from citrus fruits, possess several pharmaceutical properties. This study firstly explores the cardioprotective effects of hesperidin and hesperetin against chemotherapy-induced cardiotoxicity mechanisms, emphasizing their potential as adjunctive therapies. Key literature gaps are identified, and further mechanistic studies will be proposed. The findings underscore the translational potential of these flavonoids, advocating for rigorous preclinical optimization and clinical trials to validate their efficacy and safety. This review lays a foundation for integrating natural compounds into cardioprotective strategies in oncology. A systematic search was conducted in databases (PubMed, Scopus, ISI) until May 2025, according to PRISMA principles. The search terms were chosen according to our research objective and queried in the title and abstract. Following the screening of 82 papers, twelve articles were selected based on our inclusion and exclusion criteria. Based on the evaluated results, chemotherapy adversely affects cardiac tissue, leading to elevated risks of morbidity and mortality. Co-administration of hesperidin and hesperetin with chemotherapy prevents heart injury and preserves cardiac function, maintaining it almost like a normal heart. The protective role of hesperidin and hesperetin is based on their ability to fight free radicals, reduce inflammation, and stop cell death. Nonclinical investigations indicate that hesperidin and hesperetin ameliorate chemotherapy-induced cardiotoxicity. Nonetheless, they may influence the efficacy of anticancer medications, which primarily function by elevating oxidants, inflammation, and apoptosis. This indicates that meticulously designed trials are necessary to evaluate the efficacy and safety of this combination along with the synergistic potential of them in preventing chemotherapy-induced cardiotoxicity while maintaining anticancer effectiveness.

橙皮苷/橙皮素抗化疗引起的心脏毒性的作用:非临床研究的系统综述。
尽管化疗药物在癌症治疗中的作用不可否认,但它们的施用可能与各种副作用有关。心脏损伤是与化疗药物诱导相关的最重要的副作用之一。由于心脏是一个重要的器官,心脏毒性经常阻止临床医生继续化疗。橙皮苷和橙皮苷是一类从柑橘类水果中提取的类黄酮,具有多种药用特性。本研究首先探讨了橙皮苷和橙皮素对化疗引起的心脏毒性的保护作用机制,强调了它们作为辅助治疗的潜力。关键的文献空白已确定,并提出进一步的机制研究。研究结果强调了这些类黄酮的转化潜力,提倡严格的临床前优化和临床试验,以验证其有效性和安全性。这一综述为将天然化合物整合到肿瘤的心脏保护策略中奠定了基础。根据PRISMA原则,系统检索数据库(PubMed, Scopus, ISI)至2025年5月。根据我们的研究目的选择检索词,并在标题和摘要中查询。在对82篇论文进行筛选后,根据我们的纳入和排除标准选择了12篇文章。根据评估结果,化疗对心脏组织有不利影响,导致发病率和死亡率升高。橙皮苷和橙皮素联合化疗可防止心脏损伤并保持心脏功能,使其几乎与正常心脏一样。橙皮苷和橙皮素的保护作用是基于它们对抗自由基、减少炎症和阻止细胞死亡的能力。非临床研究表明橙皮苷和橙皮素可以改善化疗引起的心脏毒性。尽管如此,它们可能会影响抗癌药物的功效,抗癌药物的主要作用是提高氧化剂、炎症和细胞凋亡。这表明精心设计的试验是必要的,以评估这种组合的有效性和安全性,以及它们在预防化疗引起的心脏毒性方面的协同潜力,同时保持抗癌效果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
10.90
自引率
1.70%
发文量
360
审稿时长
1 months
期刊介绍: Cancer Cell International publishes articles on all aspects of cancer cell biology, originating largely from, but not limited to, work using cell culture techniques. The journal focuses on novel cancer studies reporting data from biological experiments performed on cells grown in vitro, in two- or three-dimensional systems, and/or in vivo (animal experiments). These types of experiments have provided crucial data in many fields, from cell proliferation and transformation, to epithelial-mesenchymal interaction, to apoptosis, and host immune response to tumors. Cancer Cell International also considers articles that focus on novel technologies or novel pathways in molecular analysis and on epidemiological studies that may affect patient care, as well as articles reporting translational cancer research studies where in vitro discoveries are bridged to the clinic. As such, the journal is interested in laboratory and animal studies reporting on novel biomarkers of tumor progression and response to therapy and on their applicability to human cancers.
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