Francesca Milano, Alessia Nito, Annalisa Caputo, Antonio Gaballo, Marco Marradi, Alessandra Quarta, Andrea Ragusa
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引用次数: 0
Abstract
Glutathione (GSH), a tripeptide essential for maintaining redox balance in the human body, plays a critical role in protecting cells from oxidative stress. A deficiency in GSH is linked to increased oxidative damage and the progression of various disorders, including cancer and neurological diseases. Herein, gold nanoparticles (Au NPs) coated with GSH and further functionalized with galactose moieties are developed to selectively target glucose transporters (GLUT), which is overexpressed on the surface of the blood-brain barrier (BBB) and could be exploited for the selective recognition and internalization of the Au@GSH-Gal NPs, that could then exert an antioxidant effect. As a proof of concept, brain cancer cells are treated with Au@GSH-Gal NPs, evidencing their increased internalization and a significant reduction of H2O2-induced oxidative stress.
期刊介绍：
ChemBioChem (Impact Factor 2018: 2.641) publishes important breakthroughs across all areas at the interface of chemistry and biology, including the fields of chemical biology, bioorganic chemistry, bioinorganic chemistry, synthetic biology, biocatalysis, bionanotechnology, and biomaterials. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies, and supported by the Asian Chemical Editorial Society (ACES).
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